Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells
Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promisin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/6/1372 |
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| author | Helena Moreira Anna Szyjka Justyna Grzesik Katarzyna Pelc Magdalena Żuk Anna Kulma Fathi Emhemmed Christian D. Muller Kazimierz Gąsiorowski Ewa Barg |
| author_facet | Helena Moreira Anna Szyjka Justyna Grzesik Katarzyna Pelc Magdalena Żuk Anna Kulma Fathi Emhemmed Christian D. Muller Kazimierz Gąsiorowski Ewa Barg |
| author_sort | Helena Moreira |
| collection | DOAJ |
| description | Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promising phytochemicals for colon cancer therapy, owing to their pleiotropic activity that enables them to interact with various biological targets. In the present study, the anticancer activities of both compounds were investigated in metastatic colon cancer cells (LoVo cells) and cancer stem-like cells (LoVo/DX). We showed that celastrol is a very potent anti-tumor compound against metastatic colon cancer, capable of attenuating CSC-like cells at the molecular and cellular levels. In contrast, resveratrol has a much greater effect on colon cancer cells that are expressing standard sensitivity to anticancer drugs, than on CSC-like cells. In addition, both polyphenols have different influences on the expression of <i>SIRT</i> genes, which seems to be at least partly related to their anti-tumor activity. |
| first_indexed | 2024-03-09T20:02:58Z |
| format | Article |
| id | doaj.art-7c725ada553a4853b492683412ce20c2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:02:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7c725ada553a4853b492683412ce20c22023-11-24T00:39:59ZengMDPI AGCancers2072-66942022-03-01146137210.3390/cancers14061372Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like CellsHelena Moreira0Anna Szyjka1Justyna Grzesik2Katarzyna Pelc3Magdalena Żuk4Anna Kulma5Fathi Emhemmed6Christian D. Muller7Kazimierz Gąsiorowski8Ewa Barg9Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Genetic Biochemistry, Faculty of Biotechnology, University of Wroclaw, 50-137 Wroclaw, PolandDepartment of Genetic Biochemistry, Faculty of Biotechnology, University of Wroclaw, 50-137 Wroclaw, PolandDepartment of Genetic Biochemistry, Faculty of Biotechnology, University of Wroclaw, 50-137 Wroclaw, PolandIPHC, UMR 7178 CNRS, Faculty of Pharmacy, University of Strasbourg, 67081 Illkirch, FranceIPHC, UMR 7178 CNRS, Faculty of Pharmacy, University of Strasbourg, 67081 Illkirch, FranceDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, PolandMetastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promising phytochemicals for colon cancer therapy, owing to their pleiotropic activity that enables them to interact with various biological targets. In the present study, the anticancer activities of both compounds were investigated in metastatic colon cancer cells (LoVo cells) and cancer stem-like cells (LoVo/DX). We showed that celastrol is a very potent anti-tumor compound against metastatic colon cancer, capable of attenuating CSC-like cells at the molecular and cellular levels. In contrast, resveratrol has a much greater effect on colon cancer cells that are expressing standard sensitivity to anticancer drugs, than on CSC-like cells. In addition, both polyphenols have different influences on the expression of <i>SIRT</i> genes, which seems to be at least partly related to their anti-tumor activity.https://www.mdpi.com/2072-6694/14/6/1372cancer stem cellscolon cancercelastrolresveratrolsirtuins |
| spellingShingle | Helena Moreira Anna Szyjka Justyna Grzesik Katarzyna Pelc Magdalena Żuk Anna Kulma Fathi Emhemmed Christian D. Muller Kazimierz Gąsiorowski Ewa Barg Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells Cancers cancer stem cells colon cancer celastrol resveratrol sirtuins |
| title | Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells |
| title_full | Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells |
| title_fullStr | Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells |
| title_full_unstemmed | Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells |
| title_short | Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells |
| title_sort | celastrol and resveratrol modulate em sirt em genes expression and exert anticancer activity in colon cancer cells and cancer stem like cells |
| topic | cancer stem cells colon cancer celastrol resveratrol sirtuins |
| url | https://www.mdpi.com/2072-6694/14/6/1372 |
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