Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells

Celastrol and Resveratrol Modulate <em>SIRT</em> Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells

Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promisin...

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Bibliographic Details
Main Authors: Helena Moreira, Anna Szyjka, Justyna Grzesik, Katarzyna Pelc, Magdalena Żuk, Anna Kulma, Fathi Emhemmed, Christian D. Muller, Kazimierz Gąsiorowski, Ewa Barg
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
cancer stem cells
colon cancer
celastrol
resveratrol
sirtuins
Online Access:https://www.mdpi.com/2072-6694/14/6/1372

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