Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women
Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1809 |
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| author | Konstantinos Sfakianoudis Mara Simopoulou Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Anna Rapani Polina Giannelou Nikolaos Nitsos Georgia Kokkali Michael Koutsilieris Konstantinos Pantos |
| author_facet | Konstantinos Sfakianoudis Mara Simopoulou Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Anna Rapani Polina Giannelou Nikolaos Nitsos Georgia Kokkali Michael Koutsilieris Konstantinos Pantos |
| author_sort | Konstantinos Sfakianoudis |
| collection | DOAJ |
| description | Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency. |
| first_indexed | 2024-03-10T19:16:06Z |
| format | Article |
| id | doaj.art-7c731d8d321a4a2e96332dc68113c9cc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:16:06Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7c731d8d321a4a2e96332dc68113c9cc2023-11-20T03:25:30ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196180910.3390/jcm9061809Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder WomenKonstantinos Sfakianoudis0Mara Simopoulou1Sokratis Grigoriadis2Agni Pantou3Petroula Tsioulou4Evangelos Maziotis5Anna Rapani6Polina Giannelou7Nikolaos Nitsos8Georgia Kokkali9Michael Koutsilieris10Konstantinos Pantos11Centre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceCentre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceCentre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceCentre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceCentre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceCentre for Human Reproduction, Genesis Athens Clinic, 14–16, Papanikoli, 15232 Athens, GreeceIntraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency.https://www.mdpi.com/2077-0383/9/6/1809platelet-rich plasmaintraovarian infusionovarian rejuvenationovarian reservepoor respondersperimenopause |
| spellingShingle | Konstantinos Sfakianoudis Mara Simopoulou Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Anna Rapani Polina Giannelou Nikolaos Nitsos Georgia Kokkali Michael Koutsilieris Konstantinos Pantos Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women Journal of Clinical Medicine platelet-rich plasma intraovarian infusion ovarian rejuvenation ovarian reserve poor responders perimenopause |
| title | Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women |
| title_full | Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women |
| title_fullStr | Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women |
| title_full_unstemmed | Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women |
| title_short | Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women |
| title_sort | reactivating ovarian function through autologous platelet rich plasma intraovarian infusion pilot data on premature ovarian insufficiency perimenopausal menopausal and poor responder women |
| topic | platelet-rich plasma intraovarian infusion ovarian rejuvenation ovarian reserve poor responders perimenopause |
| url | https://www.mdpi.com/2077-0383/9/6/1809 |
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