Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

Summary: Little is known of the brain mechanisms that mediate sex-specific autism symptoms. Here, we demonstrate that deletion of the autism spectrum disorder (ASD)-risk gene, Pten, in neocortical pyramidal neurons (NSEPten knockout [KO]) results in robust cortical circuit hyperexcitability selectiv...

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Bibliographic Details
Main Authors: Gemma Molinaro, Jacob E. Bowles, Katilynne Croom, Darya Gonzalez, Saba Mirjafary, Shari G. Birnbaum, Khaleel A. Razak, Jay R. Gibson, Kimberly M. Huber
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472400384X

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