Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement of a TRBV gene to the partially rearranged D-J...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Alexander Y. Komkov
التنسيق: مقال
اللغة:English
منشور في: Frontiers Media S.A. 2023-09-01
سلاسل:Frontiers in Immunology
الموضوعات:
TRB repertoire
VDJ recombination
NGS - next generation sequencing
T cell
Thymus
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1245175/full

الانترنت

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1245175/full

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