Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas
This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558617303470 |
| _version_ | 1818192246526181376 |
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| author | Bryan Oronsky Patrick C. Ma Daniel Morgensztern Corey A. Carter |
| author_facet | Bryan Oronsky Patrick C. Ma Daniel Morgensztern Corey A. Carter |
| author_sort | Bryan Oronsky |
| collection | DOAJ |
| description | This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two groups on the basis of clinical behavior, histology, and proliferation rate: well differentiated (low grade to intermediate grade) neuroendocrine tumors and poorly differentiated (high grade) neuroendocrine carcinoma (Bosman et al., 2010)2; this histological categorization/dichotomization is highly clinically relevant with respect to impact on treatment and prognosis even though it is not absolute since a subset of tumors with a low-grade appearance behaves similarly to high-grade lesions. Given the relative dearth of evidenced-based literature about this orphan disease as a whole (Modlin et al., 2008),3 since the focus of most articles is on particular anatomic subtypes of NENs (i.e., gastroenteropancreatic or pulmonary), the purpose of this review is to summarize the presentation, pathophysiology, staging, current standard of care treatments, and active areas of current research. |
| first_indexed | 2024-12-12T00:27:27Z |
| format | Article |
| id | doaj.art-7c7699169d5b4bed9eab877d1bf9d686 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-12-12T00:27:27Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-7c7699169d5b4bed9eab877d1bf9d6862022-12-22T00:44:35ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022017-12-011912991100210.1016/j.neo.2017.09.002Nothing But NET: A Review of Neuroendocrine Tumors and CarcinomasBryan Oronsky0Patrick C. Ma1Daniel Morgensztern2Corey A. Carter3EpicentRx Inc, 4445 Eastgate Mall, Suite 200, San Diego, CA 92121, USAWest Virginia University, Mary Babb Randolph Cancer Center, 8901 Wisconsin Ave., PO Box 9162, Morgantown, WV 26506, USAWashington University School of Medicine, Division of Oncology, 660 S. Euclid, Box 8056, St. Louis, MO 63110, USAWalter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889, USAThis review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two groups on the basis of clinical behavior, histology, and proliferation rate: well differentiated (low grade to intermediate grade) neuroendocrine tumors and poorly differentiated (high grade) neuroendocrine carcinoma (Bosman et al., 2010)2; this histological categorization/dichotomization is highly clinically relevant with respect to impact on treatment and prognosis even though it is not absolute since a subset of tumors with a low-grade appearance behaves similarly to high-grade lesions. Given the relative dearth of evidenced-based literature about this orphan disease as a whole (Modlin et al., 2008),3 since the focus of most articles is on particular anatomic subtypes of NENs (i.e., gastroenteropancreatic or pulmonary), the purpose of this review is to summarize the presentation, pathophysiology, staging, current standard of care treatments, and active areas of current research.http://www.sciencedirect.com/science/article/pii/S1476558617303470 |
| spellingShingle | Bryan Oronsky Patrick C. Ma Daniel Morgensztern Corey A. Carter Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas Neoplasia: An International Journal for Oncology Research |
| title | Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas |
| title_full | Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas |
| title_fullStr | Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas |
| title_full_unstemmed | Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas |
| title_short | Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas |
| title_sort | nothing but net a review of neuroendocrine tumors and carcinomas |
| url | http://www.sciencedirect.com/science/article/pii/S1476558617303470 |
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