Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma
Purpose: Ripasudil is a class of drug which alters the trabecular meshwork to increase the aqueous outflow and has been shown to be effective in pseudoexfoliative glaucoma (PXF G). This study aimed at assessing the efficacy and safety profile of ripasudil as an adjunct treatment in patients with PXF...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=7;spage=2756;epage=2759;aulast=Mohapatra |
| _version_ | 1797738732980273152 |
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| author | Sumita Mohapatra Subhodeep Thakur Bijnya B Panda Priti Das |
| author_facet | Sumita Mohapatra Subhodeep Thakur Bijnya B Panda Priti Das |
| author_sort | Sumita Mohapatra |
| collection | DOAJ |
| description | Purpose: Ripasudil is a class of drug which alters the trabecular meshwork to increase the aqueous outflow and has been shown to be effective in pseudoexfoliative glaucoma (PXF G). This study aimed at assessing the efficacy and safety profile of ripasudil as an adjunct treatment in patients with PXF G at maximal tolerated antiglaucoma medications. Methods: In this prospective, interventional study, 40 patients with PXF G were enrolled between May 2021 and Jan 2022. Ripasudil 0.4% was started as an adjunctive drug to the ongoing antiglaucoma medications. On follow-up visits at 1, 3, and 6 months, the visual acuity, intraocular pressure (IOP), anterior segment, and fundus findings were evaluated. The premedication and postmedication IOP values were compared by paired t-test, and a P-value <0.05 was considered statistically significant. Results: Average age at recruitment was 60.02 ± 8.74 years. Baseline premedication IOP was 25.375 ± 3.276 mmHg. IOP reduction at 6 months was found to be statistically significant in all patients, with the maximal response being 24.13%. Also, 87.5% (35/40) of patients reached target IOP or even lower IOP at the end of study. There was no statistically significant association between the PXF grade and IOP. However, the grade of inferior iridocorneal angle pigmentation was found to be higher in eyes with elevated IOP (P < 0.05). Only three patients developed conjunctival hyperemia as an adverse reaction, which was mild and transient. Conclusion: Ripasudil showed additional IOP-lowering effect with other antiglaucoma medications and exhibited no significant side effects. |
| first_indexed | 2024-03-12T13:47:10Z |
| format | Article |
| id | doaj.art-7c78ef60e13d49cf891a8834bffbab41 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-12T13:47:10Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-7c78ef60e13d49cf891a8834bffbab412023-08-23T08:23:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017172756275910.4103/IJO.IJO_659_23Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucomaSumita MohapatraSubhodeep ThakurBijnya B PandaPriti DasPurpose: Ripasudil is a class of drug which alters the trabecular meshwork to increase the aqueous outflow and has been shown to be effective in pseudoexfoliative glaucoma (PXF G). This study aimed at assessing the efficacy and safety profile of ripasudil as an adjunct treatment in patients with PXF G at maximal tolerated antiglaucoma medications. Methods: In this prospective, interventional study, 40 patients with PXF G were enrolled between May 2021 and Jan 2022. Ripasudil 0.4% was started as an adjunctive drug to the ongoing antiglaucoma medications. On follow-up visits at 1, 3, and 6 months, the visual acuity, intraocular pressure (IOP), anterior segment, and fundus findings were evaluated. The premedication and postmedication IOP values were compared by paired t-test, and a P-value <0.05 was considered statistically significant. Results: Average age at recruitment was 60.02 ± 8.74 years. Baseline premedication IOP was 25.375 ± 3.276 mmHg. IOP reduction at 6 months was found to be statistically significant in all patients, with the maximal response being 24.13%. Also, 87.5% (35/40) of patients reached target IOP or even lower IOP at the end of study. There was no statistically significant association between the PXF grade and IOP. However, the grade of inferior iridocorneal angle pigmentation was found to be higher in eyes with elevated IOP (P < 0.05). Only three patients developed conjunctival hyperemia as an adverse reaction, which was mild and transient. Conclusion: Ripasudil showed additional IOP-lowering effect with other antiglaucoma medications and exhibited no significant side effects.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=7;spage=2756;epage=2759;aulast=Mohapatraintraocular pressurepseudoexfoliative glaucomarho kinase inhibitorripasudilrock inhibitor |
| spellingShingle | Sumita Mohapatra Subhodeep Thakur Bijnya B Panda Priti Das Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma Indian Journal of Ophthalmology intraocular pressure pseudoexfoliative glaucoma rho kinase inhibitor ripasudil rock inhibitor |
| title | Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| title_full | Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| title_fullStr | Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| title_full_unstemmed | Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| title_short | Role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| title_sort | role of ripasudil as an adjunct treatment in the management of pseudoexfoliative glaucoma |
| topic | intraocular pressure pseudoexfoliative glaucoma rho kinase inhibitor ripasudil rock inhibitor |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=7;spage=2756;epage=2759;aulast=Mohapatra |
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