Small cell lung cancer transformation during antitumor therapies: A systematic review
Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-08-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0321 |
| _version_ | 1797998374832570368 |
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| author | Chai Xing Zhang Xinru Li Wenqian Chai Jin |
| author_facet | Chai Xing Zhang Xinru Li Wenqian Chai Jin |
| author_sort | Chai Xing |
| collection | DOAJ |
| description | Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it. |
| first_indexed | 2024-04-11T10:47:42Z |
| format | Article |
| id | doaj.art-7c7b5d0ce5b64da0a7fff78444a2a7a8 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-11T10:47:42Z |
| publishDate | 2021-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-7c7b5d0ce5b64da0a7fff78444a2a7a82022-12-22T04:29:00ZengDe GruyterOpen Medicine2391-54632021-08-011611160116710.1515/med-2021-0321Small cell lung cancer transformation during antitumor therapies: A systematic reviewChai Xing0Zhang Xinru1Li Wenqian2Chai Jin3Department of Procurement Center, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Pharmacy, The Second Hospital of Jilin University, Changchun, Jilin, 130041, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, 130021, ChinaDepartment of Pharmacy, The Second Hospital of Jilin University, No.218 Ziqiang Street, Nanguan District, Changchun, Jilin, 130041, ChinaLung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.https://doi.org/10.1515/med-2021-0321transformationnsclcsclc |
| spellingShingle | Chai Xing Zhang Xinru Li Wenqian Chai Jin Small cell lung cancer transformation during antitumor therapies: A systematic review Open Medicine transformation nsclc sclc |
| title | Small cell lung cancer transformation during antitumor therapies: A systematic review |
| title_full | Small cell lung cancer transformation during antitumor therapies: A systematic review |
| title_fullStr | Small cell lung cancer transformation during antitumor therapies: A systematic review |
| title_full_unstemmed | Small cell lung cancer transformation during antitumor therapies: A systematic review |
| title_short | Small cell lung cancer transformation during antitumor therapies: A systematic review |
| title_sort | small cell lung cancer transformation during antitumor therapies a systematic review |
| topic | transformation nsclc sclc |
| url | https://doi.org/10.1515/med-2021-0321 |
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