A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events.

A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events.

BACKGROUND AND PURPOSE: Extracellular adenosine triphosphate (ATP) regulates inflammatory cells by activation of the P2X(7) receptor. We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this h...

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Main Authors: Olof Gidlöf, J Gustav Smith, Olle Melander, Håkan Lövkvist, Bo Hedblad, Gunnar Engström, Peter Nilsson, Joyce Carlson, Göran Berglund, Sandra Olsson, Katarina Jood, Christina Jern, Bo Norrving, Arne Lindgren, David Erlinge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360776?pdf=render

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