Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches
Hepatocellular carcinoma (HCC) remains a global health challenge, representing the third leading cause of cancer deaths worldwide. Although therapeutic advances have been made in the few last years, the prognosis remains poor. Thus, there is a dire need to develop novel therapeutic strategies. In th...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/4/1249 |
| _version_ | 1797603884436291584 |
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| author | Tanja Jesenko Simona Kranjc Brezar Maja Cemazar Alice Biasin Domenico Tierno Bruna Scaggiante Mario Grassi Chiara Grassi Barbara Dapas Nhung Hai Truong Michela Abrami Fabrizio Zanconati Deborah Bonazza Flavio Rizzolio Salvatore Parisi Giorgia Pastorin Gabriele Grassi |
| author_facet | Tanja Jesenko Simona Kranjc Brezar Maja Cemazar Alice Biasin Domenico Tierno Bruna Scaggiante Mario Grassi Chiara Grassi Barbara Dapas Nhung Hai Truong Michela Abrami Fabrizio Zanconati Deborah Bonazza Flavio Rizzolio Salvatore Parisi Giorgia Pastorin Gabriele Grassi |
| author_sort | Tanja Jesenko |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) remains a global health challenge, representing the third leading cause of cancer deaths worldwide. Although therapeutic advances have been made in the few last years, the prognosis remains poor. Thus, there is a dire need to develop novel therapeutic strategies. In this regard, two approaches can be considered: (1) the identification of tumor-targeted delivery systems and (2) the targeting of molecule(s) whose aberrant expression is confined to tumor cells. In this work, we focused on the second approach. Among the different kinds of possible target molecules, we discuss the potential therapeutic value of targeting non-coding RNAs (ncRNAs), which include micro interfering RNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). These molecules represent the most significant RNA transcripts in cells and can regulate many HCC features, including proliferation, apoptosis, invasion and metastasis. In the first part of the review, the main characteristics of HCC and ncRNAs are described. The involvement of ncRNAs in HCC is then presented over five sections: (a) miRNAs, (b) lncRNAs, (c) circRNAs, (d) ncRNAs and drug resistance and (e) ncRNAs and liver fibrosis. Overall, this work provides the reader with the most recent state-of-the-art approaches in this field, highlighting key trends and opportunities for more advanced and efficacious HCC treatments. |
| first_indexed | 2024-03-11T04:38:19Z |
| format | Article |
| id | doaj.art-7c7dcf89c2694849bf0728a6e1b2b462 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:38:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7c7dcf89c2694849bf0728a6e1b2b4622023-11-17T20:54:50ZengMDPI AGPharmaceutics1999-49232023-04-01154124910.3390/pharmaceutics15041249Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic ApproachesTanja Jesenko0Simona Kranjc Brezar1Maja Cemazar2Alice Biasin3Domenico Tierno4Bruna Scaggiante5Mario Grassi6Chiara Grassi7Barbara Dapas8Nhung Hai Truong9Michela Abrami10Fabrizio Zanconati11Deborah Bonazza12Flavio Rizzolio13Salvatore Parisi14Giorgia Pastorin15Gabriele Grassi16Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI-1000 Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI-1000 Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI-1000 Ljubljana, SloveniaDepartment of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, ItalyDegree Course in Medicine, University of Trieste, I-34149 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyFaculty of Biology and Biotechnology, VNUHCM-University of Science, Ho Chi Minh City 70000, VietnamDepartment of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume, 447, I-34149 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume, 447, I-34149 Trieste, ItalyPathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, I-33081 Aviano, ItalyDepartment of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, I-30172 Venezia, ItalyPharmacy Department, National University of Singapore, Block S9, Level 15, 4 Science Drive 2, Singapore 117544, SingaporeDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyHepatocellular carcinoma (HCC) remains a global health challenge, representing the third leading cause of cancer deaths worldwide. Although therapeutic advances have been made in the few last years, the prognosis remains poor. Thus, there is a dire need to develop novel therapeutic strategies. In this regard, two approaches can be considered: (1) the identification of tumor-targeted delivery systems and (2) the targeting of molecule(s) whose aberrant expression is confined to tumor cells. In this work, we focused on the second approach. Among the different kinds of possible target molecules, we discuss the potential therapeutic value of targeting non-coding RNAs (ncRNAs), which include micro interfering RNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). These molecules represent the most significant RNA transcripts in cells and can regulate many HCC features, including proliferation, apoptosis, invasion and metastasis. In the first part of the review, the main characteristics of HCC and ncRNAs are described. The involvement of ncRNAs in HCC is then presented over five sections: (a) miRNAs, (b) lncRNAs, (c) circRNAs, (d) ncRNAs and drug resistance and (e) ncRNAs and liver fibrosis. Overall, this work provides the reader with the most recent state-of-the-art approaches in this field, highlighting key trends and opportunities for more advanced and efficacious HCC treatments.https://www.mdpi.com/1999-4923/15/4/1249hepatocellular carcinomalifer fibrosismicro interfering RNAslong non-coding RNAscircular RNAs |
| spellingShingle | Tanja Jesenko Simona Kranjc Brezar Maja Cemazar Alice Biasin Domenico Tierno Bruna Scaggiante Mario Grassi Chiara Grassi Barbara Dapas Nhung Hai Truong Michela Abrami Fabrizio Zanconati Deborah Bonazza Flavio Rizzolio Salvatore Parisi Giorgia Pastorin Gabriele Grassi Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches Pharmaceutics hepatocellular carcinoma lifer fibrosis micro interfering RNAs long non-coding RNAs circular RNAs |
| title | Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches |
| title_full | Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches |
| title_fullStr | Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches |
| title_full_unstemmed | Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches |
| title_short | Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches |
| title_sort | targeting non coding rnas for the development of novel hepatocellular carcinoma therapeutic approaches |
| topic | hepatocellular carcinoma lifer fibrosis micro interfering RNAs long non-coding RNAs circular RNAs |
| url | https://www.mdpi.com/1999-4923/15/4/1249 |
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