Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release
Abstract Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-10-01
|
| Series: | Friction |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40544-022-0648-z |
| _version_ | 1797863544437342208 |
|---|---|
| author | Xiaowei Mao Kexin Chen Yanlong Zhao Chunrong Xiong Jing Luo Yuguang Wang Bo Wang Hongyu Zhang |
| author_facet | Xiaowei Mao Kexin Chen Yanlong Zhao Chunrong Xiong Jing Luo Yuguang Wang Bo Wang Hongyu Zhang |
| author_sort | Xiaowei Mao |
| collection | DOAJ |
| description | Abstract Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide—poly(2-methacryloyloxyethyl phosphorylcholine) (DMA—MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA—MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis. |
| first_indexed | 2024-04-09T22:38:15Z |
| format | Article |
| id | doaj.art-7c814a1fb2de496d9790c0860d0e2d68 |
| institution | Directory Open Access Journal |
| issn | 2223-7690 2223-7704 |
| language | English |
| last_indexed | 2024-04-09T22:38:15Z |
| publishDate | 2022-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Friction |
| spelling | doaj.art-7c814a1fb2de496d9790c0860d0e2d682023-03-22T12:21:21ZengSpringerOpenFriction2223-76902223-77042022-10-011171194121110.1007/s40544-022-0648-zBioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug releaseXiaowei Mao0Kexin Chen1Yanlong Zhao2Chunrong Xiong3Jing Luo4Yuguang Wang5Bo Wang6Hongyu Zhang7School of Chemical Engineering and Technology, Hainan UniversityPeking University School of Nursing & National Engineering Laboratory for Digital and Material Technology of StomatologyState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua UniversitySchool of Chemical Engineering and Technology, Hainan UniversityBeijing Research Institute of Automation for Machinery Industry Co., Ltd.Center of Digital Dentistry, Peking University School and Hospital of Stomatology & NHC Research Center of Engineering and Technology for Computerized DentistryCollege of Chemical and Biological Engineering, Shandong University of Science and TechnologyState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua UniversityAbstract Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide—poly(2-methacryloyloxyethyl phosphorylcholine) (DMA—MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA—MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.https://doi.org/10.1007/s40544-022-0648-zsurface functionalizationphosphorylcholine coatingmesoporous silica nanoparticleshydration lubricationosteoarthritis |
| spellingShingle | Xiaowei Mao Kexin Chen Yanlong Zhao Chunrong Xiong Jing Luo Yuguang Wang Bo Wang Hongyu Zhang Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release Friction surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis |
| title | Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| title_full | Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| title_fullStr | Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| title_full_unstemmed | Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| title_short | Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| title_sort | bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release |
| topic | surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis |
| url | https://doi.org/10.1007/s40544-022-0648-z |
| work_keys_str_mv | AT xiaoweimao bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT kexinchen bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT yanlongzhao bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT chunrongxiong bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT jingluo bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT yuguangwang bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT bowang bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease AT hongyuzhang bioinspiredsurfacefunctionalizationofbiodegradablemesoporoussilicananoparticlesforenhancedlubricationanddrugrelease |