An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance
Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-<i>O</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/10/1969 |
| _version_ | 1819112097982709760 |
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| author | Majed Alrobaian Sana Al Azwari Amany Belal Hany A. Eldeab |
| author_facet | Majed Alrobaian Sana Al Azwari Amany Belal Hany A. Eldeab |
| author_sort | Majed Alrobaian |
| collection | DOAJ |
| description | Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-<i>O</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-<i>O</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR). |
| first_indexed | 2024-12-22T04:08:06Z |
| format | Article |
| id | doaj.art-7c82bbce6acc4a25a55cfc962fbb6d5a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T04:08:06Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7c82bbce6acc4a25a55cfc962fbb6d5a2022-12-21T18:39:35ZengMDPI AGMolecules1420-30492019-05-012410196910.3390/molecules24101969molecules24101969An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological SignificanceMajed Alrobaian0Sana Al Azwari1Amany Belal2Hany A. Eldeab3Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif 5700, Saudi ArabiaDepartment of Information Technology, College of Computers and Information Technology, Taif University, Taif 5700, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi ArabiaTwo series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-<i>O</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-<i>O</i>-acetyl-β-<span style="font-variant: small-caps;">d</span>-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).https://www.mdpi.com/1420-3049/24/10/1969green chemistrymicrowave synthesispyridine galactosidesanticancer activityantimicrobialmolecular docking |
| spellingShingle | Majed Alrobaian Sana Al Azwari Amany Belal Hany A. Eldeab An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance Molecules green chemistry microwave synthesis pyridine galactosides anticancer activity antimicrobial molecular docking |
| title | An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance |
| title_full | An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance |
| title_fullStr | An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance |
| title_full_unstemmed | An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance |
| title_short | An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance |
| title_sort | eco friendly technique solvent free microwave synthesis and docking studies of some new pyridine nucleosides and their pharmacological significance |
| topic | green chemistry microwave synthesis pyridine galactosides anticancer activity antimicrobial molecular docking |
| url | https://www.mdpi.com/1420-3049/24/10/1969 |
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