Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness
Consciousness can be defined as a phenomenological experience continuously evolving. Current research showed how conscious mental activity can be subdivided into a series of atomic brain states converging to a discrete spatiotemporal pattern of global neuronal firing. Using the high temporal resolut...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223002310 |
| _version_ | 1827319207536099328 |
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| author | Piergiuseppe Liuzzi Andrea Mannini Bahia Hakiki Silvia Campagnini Anna Maria Romoli Francesca Draghi Rachele Burali Maenia Scarpino Francesca Cecchi Antonello Grippo |
| author_facet | Piergiuseppe Liuzzi Andrea Mannini Bahia Hakiki Silvia Campagnini Anna Maria Romoli Francesca Draghi Rachele Burali Maenia Scarpino Francesca Cecchi Antonello Grippo |
| author_sort | Piergiuseppe Liuzzi |
| collection | DOAJ |
| description | Consciousness can be defined as a phenomenological experience continuously evolving. Current research showed how conscious mental activity can be subdivided into a series of atomic brain states converging to a discrete spatiotemporal pattern of global neuronal firing. Using the high temporal resolution of EEG recordings in patients with a severe Acquired Brain Injury (sABI) admitted to an Intensive Rehabilitation Unit (IRU), we detected a novel endotype of consciousness from the spatiotemporal brain dynamics identified via microstate analysis. Also, we investigated whether microstate features were associated with common neurophysiological alterations. Finally, the prognostic information comprised in such descriptors was analysed in a sub-cohort of patients with prolonged Disorder of Consciousness (pDoC). Occurrence of frontally-oriented microstates (C microstate), likelihood of maintaining such brain state or transitioning to the C topography and complexity were found to be indicators of consciousness presence and levels. Features of left–right asymmetric microstates and transitions toward them were found to be negatively correlated with antero-posterior brain reorganization and EEG symmetry. Substantial differences in microstates’ sequence complexity and presence of C topography were found between groups of patients with alpha dominant background, cortical reactivity and antero-posterior gradient. Also, transitioning from left-right to antero-posterior microstates was found to be an independent predictor of consciousness recovery, stronger than consciousness levels at IRU’s admission. In conclusions, global brain dynamics measured with scale-free estimators can be considered an indicator of consciousness presence and a candidate marker of short-term recovery in patients with a pDoC. |
| first_indexed | 2024-03-08T23:12:35Z |
| format | Article |
| id | doaj.art-7c849fbdead8459685fa7216a4cf32a3 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-25T00:15:48Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-7c849fbdead8459685fa7216a4cf32a32024-03-13T04:45:31ZengElsevierNeuroImage: Clinical2213-15822024-01-0141103540Brain microstate spatio-temporal dynamics as a candidate endotype of consciousnessPiergiuseppe Liuzzi0Andrea Mannini1Bahia Hakiki2Silvia Campagnini3Anna Maria Romoli4Francesca Draghi5Rachele Burali6Maenia Scarpino7Francesca Cecchi8Antonello Grippo9IRCCS Don Carlo Gnocchi ONLUS, Firenze, Italy; Istituto di BioRobotica, Scuola Superiore Sant’Anna, Pontedera, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, Italy; Corresponding author at: IRCCS Fondazione Don Carlo Gnocchi ONLUS, via di Scandicci 269.IRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, Italy; Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Firenze, ItalyIRCCS Don Carlo Gnocchi ONLUS, Firenze, ItalyConsciousness can be defined as a phenomenological experience continuously evolving. Current research showed how conscious mental activity can be subdivided into a series of atomic brain states converging to a discrete spatiotemporal pattern of global neuronal firing. Using the high temporal resolution of EEG recordings in patients with a severe Acquired Brain Injury (sABI) admitted to an Intensive Rehabilitation Unit (IRU), we detected a novel endotype of consciousness from the spatiotemporal brain dynamics identified via microstate analysis. Also, we investigated whether microstate features were associated with common neurophysiological alterations. Finally, the prognostic information comprised in such descriptors was analysed in a sub-cohort of patients with prolonged Disorder of Consciousness (pDoC). Occurrence of frontally-oriented microstates (C microstate), likelihood of maintaining such brain state or transitioning to the C topography and complexity were found to be indicators of consciousness presence and levels. Features of left–right asymmetric microstates and transitions toward them were found to be negatively correlated with antero-posterior brain reorganization and EEG symmetry. Substantial differences in microstates’ sequence complexity and presence of C topography were found between groups of patients with alpha dominant background, cortical reactivity and antero-posterior gradient. Also, transitioning from left-right to antero-posterior microstates was found to be an independent predictor of consciousness recovery, stronger than consciousness levels at IRU’s admission. In conclusions, global brain dynamics measured with scale-free estimators can be considered an indicator of consciousness presence and a candidate marker of short-term recovery in patients with a pDoC.http://www.sciencedirect.com/science/article/pii/S2213158223002310Brain Spatio-Temporal DynamicsEEG microstatesProlonged Disorder of ConsciousnessSevere Acquired Brain Injuries |
| spellingShingle | Piergiuseppe Liuzzi Andrea Mannini Bahia Hakiki Silvia Campagnini Anna Maria Romoli Francesca Draghi Rachele Burali Maenia Scarpino Francesca Cecchi Antonello Grippo Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness NeuroImage: Clinical Brain Spatio-Temporal Dynamics EEG microstates Prolonged Disorder of Consciousness Severe Acquired Brain Injuries |
| title | Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness |
| title_full | Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness |
| title_fullStr | Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness |
| title_full_unstemmed | Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness |
| title_short | Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness |
| title_sort | brain microstate spatio temporal dynamics as a candidate endotype of consciousness |
| topic | Brain Spatio-Temporal Dynamics EEG microstates Prolonged Disorder of Consciousness Severe Acquired Brain Injuries |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223002310 |
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