Hyperreactivity of the bronchi in children, whooping cough convalescents
Objective: to assess the presence and degree of bronchial hyperreactivity in convalescents of whooping cough based on the results of bronchial provocation tests.Materials and methods. Using bronchial provocative samples with a 0,02/0,33% histamine solution and 0,33% methacholine solution on a PROVOT...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2020-10-01
|
| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/1102 |
| _version_ | 1797723339432656896 |
|---|---|
| author | Yu. V. Nesterova A. V. Orlov I. V. Babachenko |
| author_facet | Yu. V. Nesterova A. V. Orlov I. V. Babachenko |
| author_sort | Yu. V. Nesterova |
| collection | DOAJ |
| description | Objective: to assess the presence and degree of bronchial hyperreactivity in convalescents of whooping cough based on the results of bronchial provocation tests.Materials and methods. Using bronchial provocative samples with a 0,02/0,33% histamine solution and 0,33% methacholine solution on a PROVOTEST-2 apparatus from PARI, bronchial hyperreactivity was studied in 12 pertussis convalescents aged 7 to 17 years. The level of endogenous nitrogen monoxide in exhaled air (FeNO) was measured using a portable NObreath electrochemical analyzer (from Bedfont Scientific Ltd.).The results. According to the results of BPP, 6 of 12 convalescents of whooping cough were found to have bronchial hyperreactivity of varying degrees. When conducting a breath test with a histamine solution, bronchial hyperreactivity was recorded in three children, in a sample with methacholine, in five. In 3 out of 6 children with revealed signs of bronchial hyperreactivity, the history of atopy was not burdened, which suggests a connection between the pertussis and the development of bronchial hyperreactivity. A significant increase in the level of endogenous nitric monoxide (above 16 ppb) was observed in 2 out of 10 patients. Follow-up observation showed that the duration of cough with whooping cough ranged from 3 to 6 months, and in patients with positive results of several tests it was maximum. Two out of three children with bronchial asthma showed elevated levels of FeNO and samples with methacholine. Follow-up observation showed that whooping cough aggravated bronchial asthma and demanded correction therapy.Conclusion. A pilot study on the evaluation of bronchial provocative tests suggests that the formation of bronchial hyperreactivity in convalescents of whooping cough is probable, including without a history of atopy, which increases the risk of developing bronchial asthma, however, additional studies are required for a final conclusion. |
| first_indexed | 2024-03-12T10:00:23Z |
| format | Article |
| id | doaj.art-7c84b8be3de248aeb8bcc374920c2d92 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T10:00:23Z |
| publishDate | 2020-10-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-7c84b8be3de248aeb8bcc374920c2d922023-09-02T11:46:04ZrusJournal InfectologyЖурнал инфектологии2072-67322020-10-01124515710.22625/2072-6732-2020-12-4-51-57847Hyperreactivity of the bronchi in children, whooping cough convalescentsYu. V. Nesterova0A. V. Orlov1I. V. Babachenko2Детский научно-клинический центр инфекционных болезнейДетская городская больница Святой Ольги; Северо-Западный государственный медицинский университет им. И.И. МечниковаДетский научно-клинический центр инфекционных болезней; Санкт-Петербургский государственный педиатрический медицинский университетObjective: to assess the presence and degree of bronchial hyperreactivity in convalescents of whooping cough based on the results of bronchial provocation tests.Materials and methods. Using bronchial provocative samples with a 0,02/0,33% histamine solution and 0,33% methacholine solution on a PROVOTEST-2 apparatus from PARI, bronchial hyperreactivity was studied in 12 pertussis convalescents aged 7 to 17 years. The level of endogenous nitrogen monoxide in exhaled air (FeNO) was measured using a portable NObreath electrochemical analyzer (from Bedfont Scientific Ltd.).The results. According to the results of BPP, 6 of 12 convalescents of whooping cough were found to have bronchial hyperreactivity of varying degrees. When conducting a breath test with a histamine solution, bronchial hyperreactivity was recorded in three children, in a sample with methacholine, in five. In 3 out of 6 children with revealed signs of bronchial hyperreactivity, the history of atopy was not burdened, which suggests a connection between the pertussis and the development of bronchial hyperreactivity. A significant increase in the level of endogenous nitric monoxide (above 16 ppb) was observed in 2 out of 10 patients. Follow-up observation showed that the duration of cough with whooping cough ranged from 3 to 6 months, and in patients with positive results of several tests it was maximum. Two out of three children with bronchial asthma showed elevated levels of FeNO and samples with methacholine. Follow-up observation showed that whooping cough aggravated bronchial asthma and demanded correction therapy.Conclusion. A pilot study on the evaluation of bronchial provocative tests suggests that the formation of bronchial hyperreactivity in convalescents of whooping cough is probable, including without a history of atopy, which increases the risk of developing bronchial asthma, however, additional studies are required for a final conclusion.https://journal.niidi.ru/jofin/article/view/1102коклюшдетигиперреактивность бронхов |
| spellingShingle | Yu. V. Nesterova A. V. Orlov I. V. Babachenko Hyperreactivity of the bronchi in children, whooping cough convalescents Журнал инфектологии коклюш дети гиперреактивность бронхов |
| title | Hyperreactivity of the bronchi in children, whooping cough convalescents |
| title_full | Hyperreactivity of the bronchi in children, whooping cough convalescents |
| title_fullStr | Hyperreactivity of the bronchi in children, whooping cough convalescents |
| title_full_unstemmed | Hyperreactivity of the bronchi in children, whooping cough convalescents |
| title_short | Hyperreactivity of the bronchi in children, whooping cough convalescents |
| title_sort | hyperreactivity of the bronchi in children whooping cough convalescents |
| topic | коклюш дети гиперреактивность бронхов |
| url | https://journal.niidi.ru/jofin/article/view/1102 |
| work_keys_str_mv | AT yuvnesterova hyperreactivityofthebronchiinchildrenwhoopingcoughconvalescents AT avorlov hyperreactivityofthebronchiinchildrenwhoopingcoughconvalescents AT ivbabachenko hyperreactivityofthebronchiinchildrenwhoopingcoughconvalescents |