Feasibility of low-dose CT with model-based iterative image reconstruction in follow-up of patients with testicular cancer

Purpose: We examine the performance of pure model-based iterative reconstruction with reduced-dose CT in follow-up of patients with early-stage testicular cancer. Methods: Sixteen patients (mean age 35.6 ± 7.4 years) with stage I or II testicular cancer underwent conventional dose (CD) and low-dose...

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Detaylı Bibliyografya
Asıl Yazarlar: Kevin P. Murphy, Lee Crush, Siobhan B. O’Neill, James Foody, Micheál Breen, Adrian Brady, Paul J. Kelly, Derek G. Power, Paul Sweeney, Jackie Bye, Owen J. O’Connor, Michael M. Maher, Kevin N. O’Regan
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2016-01-01
Seri Bilgileri:European Journal of Radiology Open
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2352047716300028
Diğer Bilgiler
Özet:Purpose: We examine the performance of pure model-based iterative reconstruction with reduced-dose CT in follow-up of patients with early-stage testicular cancer. Methods: Sixteen patients (mean age 35.6 ± 7.4 years) with stage I or II testicular cancer underwent conventional dose (CD) and low-dose (LD) CT acquisition during CT surveillance. LD data was reconstructed with model-based iterative reconstruction (LD–MBIR). Datasets were objectively and subjectively analysed at 8 anatomical levels. Two blinded clinical reads were compared to gold-standard assessment for diagnostic accuracy. Results: Mean radiation dose reduction of 67.1% was recorded. Mean dose measurements for LD–MBIR were: thorax – 66 ± 11 mGy cm (DLP), 1.0 ± 0.2 mSv (ED), 2.0 ± 0.4 mGy (SSDE); abdominopelvic – 128 ± 38 mGy cm (DLP), 1.9 ± 0.6 mSv (ED), 3.0 ± 0.6 mGy (SSDE). Objective noise and signal-to-noise ratio values were comparable between the CD and LD–MBIR images. LD–MBIR images were superior (p < 0.001) with regard to subjective noise, streak artefact, 2-plane contrast resolution, 2-plane spatial resolution and diagnostic acceptability. All patients were correctly categorised as positive, indeterminate or negative for metastatic disease by 2 readers on LD–MBIR and CD datasets. Conclusions: MBIR facilitated a 67% reduction in radiation dose whilst producing images that were comparable or superior to conventional dose studies without loss of diagnostic utility. Keywords: Testicular cancer, Radiation dose, Low-dose computed tomography, Iterative reconstruction, Model-based iterative reconstruction
ISSN:2352-0477