Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report
Introduction:Oral metastases are rare; nevertheless, they must be considered in the differential diagnosis of lesions in patients with a previous history of malignancy or older adults. The clinical signs of oral metastasis typically comprise pain, dysphagia, ulceration, bleeding, and paresthesia. So...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-09-01
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| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | https://ijorl.mums.ac.ir/article_20120_43991746f600cffb564f254548e47611.pdf |
| _version_ | 1811205470357028864 |
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| author | Saede Atarbashi-Moghadam Ali Lotfi Shaghayegh Dowdani |
| author_facet | Saede Atarbashi-Moghadam Ali Lotfi Shaghayegh Dowdani |
| author_sort | Saede Atarbashi-Moghadam |
| collection | DOAJ |
| description | Introduction:Oral metastases are rare; nevertheless, they must be considered in the differential diagnosis of lesions in patients with a previous history of malignancy or older adults. The clinical signs of oral metastasis typically comprise pain, dysphagia, ulceration, bleeding, and paresthesia. Soft tissue sarcomas tend to affect the extremities and retroperitoneum. The most common metastases in the oral cavity are carcinomas, and sarcomas rarely metastasize to this area. Undifferentiated pleomorphic sarcoma (UPS) is a mesenchymal malignancy that infrequently affects the head and neck site. It shows a male predilection and occurs in all age groups. The lung is the most common area of distant metastasis in undifferentiated pleomorphic sarcoma.Case Report:This report presents a 61-year-old female patient with a painful bluish-purple mass of the posterior right mandibular alveolar mucosa. She had a history of thigh UPS about four years ago. An incisional biopsy was performed, and the specimen was stained with hematoxylin and eosin. Immunohistochemical antibodies for CK, S100, desmin, myogenin, MDM2, SOX10, and caldesmon were negative and focally positive for CD68. Ki-67 index was about 70%.Conclusions:This report aimed to increase awareness of a rare lesion by describing the clinical, histopathologic, and immunohistochemical findings of metastatic undifferentiated pleomorphic sarcoma of the oral cavity. |
| first_indexed | 2024-04-12T03:32:27Z |
| format | Article |
| id | doaj.art-7c855f5a14c34040a365cf059097997d |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-04-12T03:32:27Z |
| publishDate | 2022-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-7c855f5a14c34040a365cf059097997d2022-12-22T03:49:31ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2022-09-0134526526910.22038/ijorl.2022.61622.311820120Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case ReportSaede Atarbashi-Moghadam0Ali Lotfi1Shaghayegh Dowdani2Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Graduated Student, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Introduction:Oral metastases are rare; nevertheless, they must be considered in the differential diagnosis of lesions in patients with a previous history of malignancy or older adults. The clinical signs of oral metastasis typically comprise pain, dysphagia, ulceration, bleeding, and paresthesia. Soft tissue sarcomas tend to affect the extremities and retroperitoneum. The most common metastases in the oral cavity are carcinomas, and sarcomas rarely metastasize to this area. Undifferentiated pleomorphic sarcoma (UPS) is a mesenchymal malignancy that infrequently affects the head and neck site. It shows a male predilection and occurs in all age groups. The lung is the most common area of distant metastasis in undifferentiated pleomorphic sarcoma.Case Report:This report presents a 61-year-old female patient with a painful bluish-purple mass of the posterior right mandibular alveolar mucosa. She had a history of thigh UPS about four years ago. An incisional biopsy was performed, and the specimen was stained with hematoxylin and eosin. Immunohistochemical antibodies for CK, S100, desmin, myogenin, MDM2, SOX10, and caldesmon were negative and focally positive for CD68. Ki-67 index was about 70%.Conclusions:This report aimed to increase awareness of a rare lesion by describing the clinical, histopathologic, and immunohistochemical findings of metastatic undifferentiated pleomorphic sarcoma of the oral cavity.https://ijorl.mums.ac.ir/article_20120_43991746f600cffb564f254548e47611.pdfcancerjawmetastasisoral cavitysoft tissue sarcoma |
| spellingShingle | Saede Atarbashi-Moghadam Ali Lotfi Shaghayegh Dowdani Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report Iranian Journal of Otorhinolaryngology cancer jaw metastasis oral cavity soft tissue sarcoma |
| title | Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report |
| title_full | Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report |
| title_fullStr | Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report |
| title_full_unstemmed | Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report |
| title_short | Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report |
| title_sort | oral metastatic undifferentiated pleomorphic sarcoma a case report |
| topic | cancer jaw metastasis oral cavity soft tissue sarcoma |
| url | https://ijorl.mums.ac.ir/article_20120_43991746f600cffb564f254548e47611.pdf |
| work_keys_str_mv | AT saedeatarbashimoghadam oralmetastaticundifferentiatedpleomorphicsarcomaacasereport AT alilotfi oralmetastaticundifferentiatedpleomorphicsarcomaacasereport AT shaghayeghdowdani oralmetastaticundifferentiatedpleomorphicsarcomaacasereport |