Puzzling Out Synaptic Vesicle 2 Family Members Functions
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 protein...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00148/full |
| _version_ | 1819238731847041024 |
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| author | Odile Bartholome Priscilla Van den Ackerveken Judit Sánchez Gil Orianne de la Brassinne Bonardeaux Pierre Leprince Rachelle Franzen Bernard Rogister Bernard Rogister |
| author_facet | Odile Bartholome Priscilla Van den Ackerveken Judit Sánchez Gil Orianne de la Brassinne Bonardeaux Pierre Leprince Rachelle Franzen Bernard Rogister Bernard Rogister |
| author_sort | Odile Bartholome |
| collection | DOAJ |
| description | Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders. |
| first_indexed | 2024-12-23T13:40:53Z |
| format | Article |
| id | doaj.art-7c8678d649d1457ea5ccf748bb0cba5a |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-23T13:40:53Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-7c8678d649d1457ea5ccf748bb0cba5a2022-12-21T17:44:52ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-05-011010.3389/fnmol.2017.00148265433Puzzling Out Synaptic Vesicle 2 Family Members FunctionsOdile Bartholome0Priscilla Van den Ackerveken1Judit Sánchez Gil2Orianne de la Brassinne Bonardeaux3Pierre Leprince4Rachelle Franzen5Bernard Rogister6Bernard Rogister7Laboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumLaboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, BelgiumDepartment of Neurology, Centre Hospitalier Universitaire de Liège (CHU), University of LiègeLiège, BelgiumSynaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00148/fullSV2 proteinSV2 functionsneurotransmissionepilepsyneurological diseases |
| spellingShingle | Odile Bartholome Priscilla Van den Ackerveken Judit Sánchez Gil Orianne de la Brassinne Bonardeaux Pierre Leprince Rachelle Franzen Bernard Rogister Bernard Rogister Puzzling Out Synaptic Vesicle 2 Family Members Functions Frontiers in Molecular Neuroscience SV2 protein SV2 functions neurotransmission epilepsy neurological diseases |
| title | Puzzling Out Synaptic Vesicle 2 Family Members Functions |
| title_full | Puzzling Out Synaptic Vesicle 2 Family Members Functions |
| title_fullStr | Puzzling Out Synaptic Vesicle 2 Family Members Functions |
| title_full_unstemmed | Puzzling Out Synaptic Vesicle 2 Family Members Functions |
| title_short | Puzzling Out Synaptic Vesicle 2 Family Members Functions |
| title_sort | puzzling out synaptic vesicle 2 family members functions |
| topic | SV2 protein SV2 functions neurotransmission epilepsy neurological diseases |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00148/full |
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