Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review
Primary hepatic lymphoma (PHL) is a rare form of non-Hodgkin lymphoma primarily affecting the liver. We present a case of an 84-year-old man diagnosed with PHL, incidentally detected during abdominal ultrasonography. The ultrasonography showed a hypoechoic nodule. When examined by CEUS, the nodule s...
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MDPI AG
2024-01-01
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| Series: | Diagnostics |
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| author | Ryosuke Taiji Nagaaki Marugami Aki Marugami Takahiro Itoh Sho Shimizu Ryota Nakano Yuki Hoda Hideki Kunichika Tetsuya Tachiiri Kiyoyuki Minamiguchi Satoshi Yamauchi Toshihiro Tanaka |
| author_facet | Ryosuke Taiji Nagaaki Marugami Aki Marugami Takahiro Itoh Sho Shimizu Ryota Nakano Yuki Hoda Hideki Kunichika Tetsuya Tachiiri Kiyoyuki Minamiguchi Satoshi Yamauchi Toshihiro Tanaka |
| author_sort | Ryosuke Taiji |
| collection | DOAJ |
| description | Primary hepatic lymphoma (PHL) is a rare form of non-Hodgkin lymphoma primarily affecting the liver. We present a case of an 84-year-old man diagnosed with PHL, incidentally detected during abdominal ultrasonography. The ultrasonography showed a hypoechoic nodule. When examined by CEUS, the nodule showed hyperenhancement in the arterial phase and hypoenhancement in the portal and late phases. Conversely, CECT demonstrated hypoenhancement through all the phases. The patient declined a tumor biopsy and opted for follow-up care. Ten months later, the lobular mass had increased from 15 mm to 65 mm, presenting as hypoechogenic and demonstrating the “vessel-penetrating sign” on color Doppler imaging. CEUS revealed reticulated enhancement, indicating intratumoral vessels. The mass displayed hypoattenuation on plain CT, hypointensity in T1-weighted images, and hyperintensity in T2-weighted images and exhibited significant restriction in diffusion-weighted images. Both CECT and contrast-enhanced MRI exhibited hypoenhancement. The patient underwent a partial hepatic segmentectomy, and the mass was pathologically diagnosed as a diffuse large B-cell lymphoma. Subsequent postoperative radiological examinations revealed no other lesions, confirming the diagnosis of PHL. Our report highlights specific ultrasonographic signs of PHL observed from an early stage and presents a review of the relevant literature. |
| first_indexed | 2024-03-08T03:58:44Z |
| format | Article |
| id | doaj.art-7c87e057ed3c4fd38c4b4b69a35c224b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T03:58:44Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7c87e057ed3c4fd38c4b4b69a35c224b2024-02-09T15:10:10ZengMDPI AGDiagnostics2075-44182024-01-0114330610.3390/diagnostics14030306Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature ReviewRyosuke Taiji0Nagaaki Marugami1Aki Marugami2Takahiro Itoh3Sho Shimizu4Ryota Nakano5Yuki Hoda6Hideki Kunichika7Tetsuya Tachiiri8Kiyoyuki Minamiguchi9Satoshi Yamauchi10Toshihiro Tanaka11Department of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanDepartment of Diagnostic and Interventional Radiology, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara 634-8522, JapanPrimary hepatic lymphoma (PHL) is a rare form of non-Hodgkin lymphoma primarily affecting the liver. We present a case of an 84-year-old man diagnosed with PHL, incidentally detected during abdominal ultrasonography. The ultrasonography showed a hypoechoic nodule. When examined by CEUS, the nodule showed hyperenhancement in the arterial phase and hypoenhancement in the portal and late phases. Conversely, CECT demonstrated hypoenhancement through all the phases. The patient declined a tumor biopsy and opted for follow-up care. Ten months later, the lobular mass had increased from 15 mm to 65 mm, presenting as hypoechogenic and demonstrating the “vessel-penetrating sign” on color Doppler imaging. CEUS revealed reticulated enhancement, indicating intratumoral vessels. The mass displayed hypoattenuation on plain CT, hypointensity in T1-weighted images, and hyperintensity in T2-weighted images and exhibited significant restriction in diffusion-weighted images. Both CECT and contrast-enhanced MRI exhibited hypoenhancement. The patient underwent a partial hepatic segmentectomy, and the mass was pathologically diagnosed as a diffuse large B-cell lymphoma. Subsequent postoperative radiological examinations revealed no other lesions, confirming the diagnosis of PHL. Our report highlights specific ultrasonographic signs of PHL observed from an early stage and presents a review of the relevant literature.https://www.mdpi.com/2075-4418/14/3/306lymphomaprimary hepatic lymphomaultrasonographycontrast-enhanced ultrasonographycomputed tomographymagnetic resonance imaging |
| spellingShingle | Ryosuke Taiji Nagaaki Marugami Aki Marugami Takahiro Itoh Sho Shimizu Ryota Nakano Yuki Hoda Hideki Kunichika Tetsuya Tachiiri Kiyoyuki Minamiguchi Satoshi Yamauchi Toshihiro Tanaka Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review Diagnostics lymphoma primary hepatic lymphoma ultrasonography contrast-enhanced ultrasonography computed tomography magnetic resonance imaging |
| title | Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review |
| title_full | Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review |
| title_fullStr | Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review |
| title_full_unstemmed | Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review |
| title_short | Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review |
| title_sort | multimodality imaging of primary hepatic lymphoma a case report and a literature review |
| topic | lymphoma primary hepatic lymphoma ultrasonography contrast-enhanced ultrasonography computed tomography magnetic resonance imaging |
| url | https://www.mdpi.com/2075-4418/14/3/306 |
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