Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group
Pakistan is the fifth most populous country with a population of 225 million and has health expenditure accounting for only 2.8 percent of gross domestic product (GDP). Accordingly, there are a limited number of haematology-oncology and transplant centers in the country. The Pakistan Blood and Marro...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2023/8865364 |
| _version_ | 1797665412812374016 |
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| author | Natasha Ali Raheel Iftikhar Muhammad Ayaz Mir Syed Waqas Bokhari Jehanzeb Ur Rehman Uzma Zaidi Shahzad Nasir Salman Naseem Adil Tariq Satti Qamar Un Nisa Chaudhry Muhammad Farhan Tasneem Farzana Tariq Ghafoor Bushra Ahsan Azhar S. Khan Farrukh Ali Khan Syeda Itrat Fatima Shafaq Abdul Samad Aliya Batool Hafiz Muhammad Nadeem Syed Nasir Abbas Bukhari Saqib Hussain Ansari Parvez Ahmed |
| author_facet | Natasha Ali Raheel Iftikhar Muhammad Ayaz Mir Syed Waqas Bokhari Jehanzeb Ur Rehman Uzma Zaidi Shahzad Nasir Salman Naseem Adil Tariq Satti Qamar Un Nisa Chaudhry Muhammad Farhan Tasneem Farzana Tariq Ghafoor Bushra Ahsan Azhar S. Khan Farrukh Ali Khan Syeda Itrat Fatima Shafaq Abdul Samad Aliya Batool Hafiz Muhammad Nadeem Syed Nasir Abbas Bukhari Saqib Hussain Ansari Parvez Ahmed |
| author_sort | Natasha Ali |
| collection | DOAJ |
| description | Pakistan is the fifth most populous country with a population of 225 million and has health expenditure accounting for only 2.8 percent of gross domestic product (GDP). Accordingly, there are a limited number of haematology-oncology and transplant centers in the country. The Pakistan Blood and Marrow Transplant (PBMT) group was established in 2020, and this report is the first activity survey from January 2021 to December 2022 focusing on the trends of matched-related donor, haploidentical, and autologous transplants in a developing country. A total of 12 transplant centers contributed data on the modified PBMT survey form retrospectively and 806 haematopoietic stem cell transplants (HSCTs) were carried out during the study duration. Allogeneic HSCT constituted 595 (73.8%) of all the transplants; this is in stark contrast to Western data, where autologous HSCT accounts for the majority of transplants. ß-thalassemia major and aplastic anemia were the commonest indications for allogeneic HSCT, in contrast to Western data, where acute leukemia is the leading transplant indication. Autologous transplants were more frequently performed for Hodgkin’s lymphoma as compared to non-Hodgkin’s lymphoma and multiple myeloma. The use of peripheral and bone marrow stem cells was comparable. A myeloablative conditioning regimen was routinely used in patients with acute leukemia. This report provides an insight of HSCT trends in Pakistan which are different from those of Western centers contributing to transplant data from South Asia. |
| first_indexed | 2024-03-11T19:44:35Z |
| format | Article |
| id | doaj.art-7c8a1debf36e40689b39228ce79d6df2 |
| institution | Directory Open Access Journal |
| issn | 2090-0015 |
| language | English |
| last_indexed | 2024-03-11T19:44:35Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj.art-7c8a1debf36e40689b39228ce79d6df22023-10-06T00:00:02ZengHindawi LimitedJournal of Transplantation2090-00152023-01-01202310.1155/2023/8865364Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant GroupNatasha Ali0Raheel Iftikhar1Muhammad Ayaz Mir2Syed Waqas Bokhari3Jehanzeb Ur Rehman4Uzma Zaidi5Shahzad Nasir6Salman Naseem Adil7Tariq Satti8Qamar Un Nisa Chaudhry9Muhammad Farhan10Tasneem Farzana11Tariq Ghafoor12Bushra Ahsan13Azhar S. Khan14Farrukh Ali Khan15Syeda Itrat Fatima16Shafaq Abdul Samad17Aliya Batool18Hafiz Muhammad Nadeem19Syed Nasir Abbas Bukhari20Saqib Hussain Ansari21Parvez Ahmed22Aga Khan UniversityArmed Forces Bone Marrow Transplant CenterShifa International HospitalShaukat Khanum Memorial Cancer HospitalArmed Forces Bone Marrow Transplant CenterNational Institute of Blood DiseasesQuaid-e-Azam International HospitalAga Khan UniversityShifa International HospitalArmed Forces Bone Marrow Transplant CenterGambat Institute of Medical SciencesThe Children’s Hospital LahoreArmed Forces Bone Marrow Transplant CenterShaukat Khanum Memorial Cancer HospitalShifa International HospitalDow University of Health SciencesPakistan Institute of Medical SciencesNational Institute of Blood DiseasesAkbar Niazi Teaching HospitalGambat Institute of Medical SciencesThe Children’s Hospital LahoreChildren’s Hospital KarachiQuaid-e-Azam International HospitalPakistan is the fifth most populous country with a population of 225 million and has health expenditure accounting for only 2.8 percent of gross domestic product (GDP). Accordingly, there are a limited number of haematology-oncology and transplant centers in the country. The Pakistan Blood and Marrow Transplant (PBMT) group was established in 2020, and this report is the first activity survey from January 2021 to December 2022 focusing on the trends of matched-related donor, haploidentical, and autologous transplants in a developing country. A total of 12 transplant centers contributed data on the modified PBMT survey form retrospectively and 806 haematopoietic stem cell transplants (HSCTs) were carried out during the study duration. Allogeneic HSCT constituted 595 (73.8%) of all the transplants; this is in stark contrast to Western data, where autologous HSCT accounts for the majority of transplants. ß-thalassemia major and aplastic anemia were the commonest indications for allogeneic HSCT, in contrast to Western data, where acute leukemia is the leading transplant indication. Autologous transplants were more frequently performed for Hodgkin’s lymphoma as compared to non-Hodgkin’s lymphoma and multiple myeloma. The use of peripheral and bone marrow stem cells was comparable. A myeloablative conditioning regimen was routinely used in patients with acute leukemia. This report provides an insight of HSCT trends in Pakistan which are different from those of Western centers contributing to transplant data from South Asia.http://dx.doi.org/10.1155/2023/8865364 |
| spellingShingle | Natasha Ali Raheel Iftikhar Muhammad Ayaz Mir Syed Waqas Bokhari Jehanzeb Ur Rehman Uzma Zaidi Shahzad Nasir Salman Naseem Adil Tariq Satti Qamar Un Nisa Chaudhry Muhammad Farhan Tasneem Farzana Tariq Ghafoor Bushra Ahsan Azhar S. Khan Farrukh Ali Khan Syeda Itrat Fatima Shafaq Abdul Samad Aliya Batool Hafiz Muhammad Nadeem Syed Nasir Abbas Bukhari Saqib Hussain Ansari Parvez Ahmed Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group Journal of Transplantation |
| title | Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group |
| title_full | Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group |
| title_fullStr | Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group |
| title_full_unstemmed | Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group |
| title_short | Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group |
| title_sort | haematopoietic stem cell transplant trends in pakistan activity survey from pakistan bone marrow transplant group |
| url | http://dx.doi.org/10.1155/2023/8865364 |
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