The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers
Abstract Background Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants. Methods The Breathing for Life Trial recruited pregnant women with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-023-01030-6 |
| _version_ | 1797397818680279040 |
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| author | Elizabeth Percival Adam M. Collison Carla Rebeca da Silva Sena Ediane De Queiroz Andrade Patricia De Gouveia Belinelo Gabriela Martins Costa Gomes Christopher Oldmeadow Vanessa E. Murphy Peter G. Gibson Wilfried Karmaus Joerg Mattes |
| author_facet | Elizabeth Percival Adam M. Collison Carla Rebeca da Silva Sena Ediane De Queiroz Andrade Patricia De Gouveia Belinelo Gabriela Martins Costa Gomes Christopher Oldmeadow Vanessa E. Murphy Peter G. Gibson Wilfried Karmaus Joerg Mattes |
| author_sort | Elizabeth Percival |
| collection | DOAJ |
| description | Abstract Background Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants. Methods The Breathing for Life Trial recruited pregnant women with asthma into a randomised controlled trial comparing usual clinical care versus inflammometry-guided asthma management in pregnancy. Four hundred fifty-seven infants from the Breathing for Life Trial birth cohort were assessed at six weeks of age. Exhaled nitric oxide was measured in unsedated, sleeping infants. Its association with local mean 24-h and mean seven-day concentrations of ozone, nitric oxide, nitrogen dioxide, carbon monoxide, sulfur dioxide, ammonia, particulate matter less than 10 μm (PM10) and less than 2.5 μm (PM2.5) in diameter was investigated. The air pollutant data were sourced from local monitoring sites of the New South Wales Air Quality Monitoring Network. The association was assessed using a ‘least absolute shrinkage and selection operator’ (LASSO) approach, multivariable regression and Spearman’s rank correlation. Results A seasonal variation was evident with higher median exhaled nitric oxide levels (13.6 ppb) in warmer months and lower median exhaled nitric oxide levels (11.0 ppb) in cooler months, P = 0.008. LASSO identified positive associations for exhaled nitric oxide with 24-h mean ammonia, seven-day mean ammonia, seven-day mean PM10, seven-day mean PM2.5, and seven-day mean ozone; and negative associations for eNO with seven-day mean carbon monoxide, 24-h mean nitric oxide and 24-h mean sulfur dioxide, with an R-square of 0.25 for the penalized coefficients. These coefficients selected by LASSO (and confounders) were entered in multivariable regression. The achieved R-square was 0.27. Conclusion In this cohort of young infants of asthmatic mothers, exhaled nitric oxide showed seasonal variation and an association with local air pollution concentrations. |
| first_indexed | 2024-03-09T01:15:41Z |
| format | Article |
| id | doaj.art-7c8befedb6ad464bb8da6affbae80ceb |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-03-09T01:15:41Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-7c8befedb6ad464bb8da6affbae80ceb2023-12-10T12:30:16ZengBMCEnvironmental Health1476-069X2023-12-0122111310.1186/s12940-023-01030-6The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothersElizabeth Percival0Adam M. Collison1Carla Rebeca da Silva Sena2Ediane De Queiroz Andrade3Patricia De Gouveia Belinelo4Gabriela Martins Costa Gomes5Christopher Oldmeadow6Vanessa E. Murphy7Peter G. Gibson8Wilfried Karmaus9Joerg Mattes10Asthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleHunter Medical Research Institute, New Lambton HeightsAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleDivision of Epidemiology, School of Public Health, and Environmental Health Science, University of MemphisAsthma & Breathing Research Centre, Hunter Medical Research Institute, University of NewcastleAbstract Background Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants. Methods The Breathing for Life Trial recruited pregnant women with asthma into a randomised controlled trial comparing usual clinical care versus inflammometry-guided asthma management in pregnancy. Four hundred fifty-seven infants from the Breathing for Life Trial birth cohort were assessed at six weeks of age. Exhaled nitric oxide was measured in unsedated, sleeping infants. Its association with local mean 24-h and mean seven-day concentrations of ozone, nitric oxide, nitrogen dioxide, carbon monoxide, sulfur dioxide, ammonia, particulate matter less than 10 μm (PM10) and less than 2.5 μm (PM2.5) in diameter was investigated. The air pollutant data were sourced from local monitoring sites of the New South Wales Air Quality Monitoring Network. The association was assessed using a ‘least absolute shrinkage and selection operator’ (LASSO) approach, multivariable regression and Spearman’s rank correlation. Results A seasonal variation was evident with higher median exhaled nitric oxide levels (13.6 ppb) in warmer months and lower median exhaled nitric oxide levels (11.0 ppb) in cooler months, P = 0.008. LASSO identified positive associations for exhaled nitric oxide with 24-h mean ammonia, seven-day mean ammonia, seven-day mean PM10, seven-day mean PM2.5, and seven-day mean ozone; and negative associations for eNO with seven-day mean carbon monoxide, 24-h mean nitric oxide and 24-h mean sulfur dioxide, with an R-square of 0.25 for the penalized coefficients. These coefficients selected by LASSO (and confounders) were entered in multivariable regression. The achieved R-square was 0.27. Conclusion In this cohort of young infants of asthmatic mothers, exhaled nitric oxide showed seasonal variation and an association with local air pollution concentrations.https://doi.org/10.1186/s12940-023-01030-6Exhaled nitric oxide (eNO)InfantAir pollutionBreathing for Life TrialSeason |
| spellingShingle | Elizabeth Percival Adam M. Collison Carla Rebeca da Silva Sena Ediane De Queiroz Andrade Patricia De Gouveia Belinelo Gabriela Martins Costa Gomes Christopher Oldmeadow Vanessa E. Murphy Peter G. Gibson Wilfried Karmaus Joerg Mattes The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers Environmental Health Exhaled nitric oxide (eNO) Infant Air pollution Breathing for Life Trial Season |
| title | The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| title_full | The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| title_fullStr | The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| title_full_unstemmed | The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| title_short | The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| title_sort | association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers |
| topic | Exhaled nitric oxide (eNO) Infant Air pollution Breathing for Life Trial Season |
| url | https://doi.org/10.1186/s12940-023-01030-6 |
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