Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology
In recent years there has been increased interest in using the immune contexture of the primary tumors to predict the patient’s prognosis. The tumor microenvironment of patients with cancers consists of different types of lymphocytes, tumor-infiltrating leukocytes, dendritic cells, and others. Diffe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/15/3628 |
| _version_ | 1797442645910355968 |
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| author | Tushar Garg Clifford R. Weiss Rahul A. Sheth |
| author_facet | Tushar Garg Clifford R. Weiss Rahul A. Sheth |
| author_sort | Tushar Garg |
| collection | DOAJ |
| description | In recent years there has been increased interest in using the immune contexture of the primary tumors to predict the patient’s prognosis. The tumor microenvironment of patients with cancers consists of different types of lymphocytes, tumor-infiltrating leukocytes, dendritic cells, and others. Different technologies can be used for the evaluation of the tumor microenvironment, all of which require a tissue or cell sample. Image-guided tissue sampling is a cornerstone in the diagnosis, stratification, and longitudinal evaluation of therapeutic efficacy for cancer patients receiving immunotherapies. Therefore, interventional radiologists (IRs) play an essential role in the evaluation of patients treated with systemically administered immunotherapies. This review provides a detailed description of different technologies used for immune assessment and analysis of the data collected from the use of these technologies. The detailed approach provided herein is intended to provide the reader with the knowledge necessary to not only interpret studies containing such data but also design and apply these tools for clinical practice and future research studies. |
| first_indexed | 2024-03-09T12:44:58Z |
| format | Article |
| id | doaj.art-7c8ce2c353b145c9a59798b1c5155319 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:44:58Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7c8ce2c353b145c9a59798b1c51553192023-11-30T22:13:23ZengMDPI AGCancers2072-66942022-07-011415362810.3390/cancers14153628Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional OncologyTushar Garg0Clifford R. Weiss1Rahul A. Sheth2Division of Vascular and Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADivision of Vascular and Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAIn recent years there has been increased interest in using the immune contexture of the primary tumors to predict the patient’s prognosis. The tumor microenvironment of patients with cancers consists of different types of lymphocytes, tumor-infiltrating leukocytes, dendritic cells, and others. Different technologies can be used for the evaluation of the tumor microenvironment, all of which require a tissue or cell sample. Image-guided tissue sampling is a cornerstone in the diagnosis, stratification, and longitudinal evaluation of therapeutic efficacy for cancer patients receiving immunotherapies. Therefore, interventional radiologists (IRs) play an essential role in the evaluation of patients treated with systemically administered immunotherapies. This review provides a detailed description of different technologies used for immune assessment and analysis of the data collected from the use of these technologies. The detailed approach provided herein is intended to provide the reader with the knowledge necessary to not only interpret studies containing such data but also design and apply these tools for clinical practice and future research studies.https://www.mdpi.com/2072-6694/14/15/3628immune profilingtumor microenvironmenttissue sectionsingle-cell characterizationspatial transcriptomicsinterventional oncology |
| spellingShingle | Tushar Garg Clifford R. Weiss Rahul A. Sheth Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology Cancers immune profiling tumor microenvironment tissue section single-cell characterization spatial transcriptomics interventional oncology |
| title | Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology |
| title_full | Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology |
| title_fullStr | Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology |
| title_full_unstemmed | Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology |
| title_short | Techniques for Profiling the Cellular Immune Response and Their Implications for Interventional Oncology |
| title_sort | techniques for profiling the cellular immune response and their implications for interventional oncology |
| topic | immune profiling tumor microenvironment tissue section single-cell characterization spatial transcriptomics interventional oncology |
| url | https://www.mdpi.com/2072-6694/14/15/3628 |
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