Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct

Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct

In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla is associated with hypertension. However, it...

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Bibliographic Details
Main Authors: Andrew C. Curnow, Sabrina R. Gonsalez, Venkateswara R. Gogulamudi, Bruna Visniauskas, Eric E. Simon, Alexis A. Gonzalez, Dewan S. A. Majid, Lucienne S. Lara, Minolfa C. Prieto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
eNOS knockout mice
cyclic GMP
L-NAME
NO donor
ODQ
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.559341/full

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