Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy
Objective: The present study aimed to evaluate the prevalence of traumatic experienced seizures (TES) and of postepileptic seizure PTSD (PS-PTSD) in patients with pharmacoresistant focal epilepsy and to explore the determining factors of TES.Methods: We conducted an observational study enrolling 107...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.669411/full |
| _version_ | 1819098166837903360 |
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| author | Sara Mariotti Sara Mariotti Damien Valentin Damien Valentin Deniz Ertan Deniz Ertan Louis Maillard Louis Maillard Louis Maillard Alexis Tarrada Alexis Tarrada Jan Chrusciel Stéphane Sanchez Raymund Schwan Raymund Schwan Raymund Schwan Jean-Pierre Vignal Jean-Pierre Vignal Louise Tyvaert Louise Tyvaert Louise Tyvaert Wissam El-Hage Wissam El-Hage Coraline Hingray Coraline Hingray Coraline Hingray |
| author_facet | Sara Mariotti Sara Mariotti Damien Valentin Damien Valentin Deniz Ertan Deniz Ertan Louis Maillard Louis Maillard Louis Maillard Alexis Tarrada Alexis Tarrada Jan Chrusciel Stéphane Sanchez Raymund Schwan Raymund Schwan Raymund Schwan Jean-Pierre Vignal Jean-Pierre Vignal Louise Tyvaert Louise Tyvaert Louise Tyvaert Wissam El-Hage Wissam El-Hage Coraline Hingray Coraline Hingray Coraline Hingray |
| author_sort | Sara Mariotti |
| collection | DOAJ |
| description | Objective: The present study aimed to evaluate the prevalence of traumatic experienced seizures (TES) and of postepileptic seizure PTSD (PS-PTSD) in patients with pharmacoresistant focal epilepsy and to explore the determining factors of TES.Methods: We conducted an observational study enrolling 107 adult refractory epilepsy patients. We used the DSM-5 criteria of traumatic events and PTSD to define TES and PS-PTSD. We assessed all traumatic life events unrelated to epilepsy, general and specific psychiatric comorbidities, and quality of life.Results: Nearly half (n = 48) of the 107 participants reported at least one TES (44.85%). Among these, one-third (n = 16) developed PS-PTSD. The TES group was more likely to experience traumatic events unrelated to epilepsy (p < 0.001), to have generalized anxiety disorder (p = 0.019), and to have specific psychiatric comorbidities [e.g., interictal dysphoric disorder (p = 0.024) or anticipatory anxiety of seizures (p = 0.005)]. They reported a severe impact of epilepsy on their life (p = 0.01). The determining factors of TES according to the multifactorial model were the experience of trauma (p = 0.008), a history of at least one psychiatric disorder (p = 0.03), and a strong tendency toward dissociation (p = 0.03).Significance: Epileptic seizures may be a traumatic experience in some patients who suffer from pharmacoresistant epilepsy and may be the source of the development of PS-PTSD. Previous trauma unrelated to epilepsy and psychiatric history are determining factors of TES. These clinical entities should be explored systematically. |
| first_indexed | 2024-12-22T00:26:40Z |
| format | Article |
| id | doaj.art-7c8e549b0c1b41b3ab1455f6ead93b1c |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T00:26:40Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-7c8e549b0c1b41b3ab1455f6ead93b1c2022-12-21T18:45:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.669411669411Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal EpilepsySara Mariotti0Sara Mariotti1Damien Valentin2Damien Valentin3Deniz Ertan4Deniz Ertan5Louis Maillard6Louis Maillard7Louis Maillard8Alexis Tarrada9Alexis Tarrada10Jan Chrusciel11Stéphane Sanchez12Raymund Schwan13Raymund Schwan14Raymund Schwan15Jean-Pierre Vignal16Jean-Pierre Vignal17Louise Tyvaert18Louise Tyvaert19Louise Tyvaert20Wissam El-Hage21Wissam El-Hage22Coraline Hingray23Coraline Hingray24Coraline Hingray25Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceUniversité de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, FrancePôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceUniversité de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceEtablissement la Teppe Tain l'Hermitage, Tain-l'Hermitage, FranceUniversité de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceCHRU de Nancy, Département de Neurologie, Nancy, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceCHRU de Nancy, Département de Neurologie, Nancy, FrancePôle Information Médicale Évaluation Performance, CH de Troyes, Troyes, FrancePôle Information Médicale Évaluation Performance, CH de Troyes, Troyes, FrancePôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceUniversité de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, FranceINSERM U1114, Université de Strasbourg, Strasbourg, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceCHRU de Nancy, Département de Neurologie, Nancy, FranceUniversité de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceCHRU de Nancy, Département de Neurologie, Nancy, FranceUMR 1253, iBrain, Université de Tours, INSERM, Tours, FranceCHU de Tours, Tours, FrancePôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceUniversité de Lorraine, CNRS, CRAN, UMR 7039, Nancy, FranceCHRU de Nancy, Département de Neurologie, Nancy, FranceObjective: The present study aimed to evaluate the prevalence of traumatic experienced seizures (TES) and of postepileptic seizure PTSD (PS-PTSD) in patients with pharmacoresistant focal epilepsy and to explore the determining factors of TES.Methods: We conducted an observational study enrolling 107 adult refractory epilepsy patients. We used the DSM-5 criteria of traumatic events and PTSD to define TES and PS-PTSD. We assessed all traumatic life events unrelated to epilepsy, general and specific psychiatric comorbidities, and quality of life.Results: Nearly half (n = 48) of the 107 participants reported at least one TES (44.85%). Among these, one-third (n = 16) developed PS-PTSD. The TES group was more likely to experience traumatic events unrelated to epilepsy (p < 0.001), to have generalized anxiety disorder (p = 0.019), and to have specific psychiatric comorbidities [e.g., interictal dysphoric disorder (p = 0.024) or anticipatory anxiety of seizures (p = 0.005)]. They reported a severe impact of epilepsy on their life (p = 0.01). The determining factors of TES according to the multifactorial model were the experience of trauma (p = 0.008), a history of at least one psychiatric disorder (p = 0.03), and a strong tendency toward dissociation (p = 0.03).Significance: Epileptic seizures may be a traumatic experience in some patients who suffer from pharmacoresistant epilepsy and may be the source of the development of PS-PTSD. Previous trauma unrelated to epilepsy and psychiatric history are determining factors of TES. These clinical entities should be explored systematically.https://www.frontiersin.org/articles/10.3389/fneur.2021.669411/fulldrug-resistant focal epilepsytraumatraumatic experienced seizurepsychiatric comorbiditiespostepileptic seizure posttraumatic stress disorderposttraumatic stress disorder |
| spellingShingle | Sara Mariotti Sara Mariotti Damien Valentin Damien Valentin Deniz Ertan Deniz Ertan Louis Maillard Louis Maillard Louis Maillard Alexis Tarrada Alexis Tarrada Jan Chrusciel Stéphane Sanchez Raymund Schwan Raymund Schwan Raymund Schwan Jean-Pierre Vignal Jean-Pierre Vignal Louise Tyvaert Louise Tyvaert Louise Tyvaert Wissam El-Hage Wissam El-Hage Coraline Hingray Coraline Hingray Coraline Hingray Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy Frontiers in Neurology drug-resistant focal epilepsy trauma traumatic experienced seizure psychiatric comorbidities postepileptic seizure posttraumatic stress disorder posttraumatic stress disorder |
| title | Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy |
| title_full | Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy |
| title_fullStr | Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy |
| title_full_unstemmed | Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy |
| title_short | Past Trauma Is Associated With a Higher Risk of Experiencing an Epileptic Seizure as Traumatic in Patients With Pharmacoresistant Focal Epilepsy |
| title_sort | past trauma is associated with a higher risk of experiencing an epileptic seizure as traumatic in patients with pharmacoresistant focal epilepsy |
| topic | drug-resistant focal epilepsy trauma traumatic experienced seizure psychiatric comorbidities postepileptic seizure posttraumatic stress disorder posttraumatic stress disorder |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.669411/full |
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