Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications
Considerable research effort has focused on the in vivo use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is EuII-conta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fchem.2018.00065/full |
| _version_ | 1828357066306093056 |
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| author | Lina A. Basal Matthew J. Allen |
| author_facet | Lina A. Basal Matthew J. Allen |
| author_sort | Lina A. Basal |
| collection | DOAJ |
| description | Considerable research effort has focused on the in vivo use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is EuII-containing complexes because the EuII/III redox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of EuII requires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete EuII-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous EuII-containing complexes. |
| first_indexed | 2024-04-14T03:09:33Z |
| format | Article |
| id | doaj.art-7c8ebfea23994eb9a0b71face6aa661f |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-14T03:09:33Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7c8ebfea23994eb9a0b71face6aa661f2022-12-22T02:15:38ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462018-03-01610.3389/fchem.2018.00065352165Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging ApplicationsLina A. BasalMatthew J. AllenConsiderable research effort has focused on the in vivo use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is EuII-containing complexes because the EuII/III redox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of EuII requires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete EuII-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous EuII-containing complexes.http://journal.frontiersin.org/article/10.3389/fchem.2018.00065/fullchelating ligandscontrast agentscoordination chemistrydivalent europiumlanthanidesmolecular imaging probes |
| spellingShingle | Lina A. Basal Matthew J. Allen Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications Frontiers in Chemistry chelating ligands contrast agents coordination chemistry divalent europium lanthanides molecular imaging probes |
| title | Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications |
| title_full | Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications |
| title_fullStr | Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications |
| title_full_unstemmed | Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications |
| title_short | Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications |
| title_sort | synthesis characterization and handling of euii containing complexes for molecular imaging applications |
| topic | chelating ligands contrast agents coordination chemistry divalent europium lanthanides molecular imaging probes |
| url | http://journal.frontiersin.org/article/10.3389/fchem.2018.00065/full |
| work_keys_str_mv | AT linaabasal synthesischaracterizationandhandlingofeuiicontainingcomplexesformolecularimagingapplications AT matthewjallen synthesischaracterizationandhandlingofeuiicontainingcomplexesformolecularimagingapplications |