Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey
BackgroundDespite the WHO's report of 24 available SARS-CoV-2 vaccines, limited data exist regarding vaccination policies for liver transplant (LT) patients. To address this, we conducted a global multi-society survey (EASL-ESOT-ELITA-ILTS) in LT centers.MethodsA digital questionnaire assessing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1332616/full |
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| author | Tommaso Di Maira Tommaso Di Maira Tommaso Di Maira Carmen Vinaixa Carmen Vinaixa Carmen Vinaixa Manhal Izzy Francesco Paolo Russo Varvara A. Kirchner Ashwin Rammohan Luca Saverio Belli Wojciech Grzegorz Polak Thomas Berg Marina Berenguer Marina Berenguer Marina Berenguer |
| author_facet | Tommaso Di Maira Tommaso Di Maira Tommaso Di Maira Carmen Vinaixa Carmen Vinaixa Carmen Vinaixa Manhal Izzy Francesco Paolo Russo Varvara A. Kirchner Ashwin Rammohan Luca Saverio Belli Wojciech Grzegorz Polak Thomas Berg Marina Berenguer Marina Berenguer Marina Berenguer |
| author_sort | Tommaso Di Maira |
| collection | DOAJ |
| description | BackgroundDespite the WHO's report of 24 available SARS-CoV-2 vaccines, limited data exist regarding vaccination policies for liver transplant (LT) patients. To address this, we conducted a global multi-society survey (EASL-ESOT-ELITA-ILTS) in LT centers.MethodsA digital questionnaire assessing vaccine policies, safety, efficacy, and center data was administered online to LT centers.ResultsOut of 168 responding centers, 46.4%, 28%, 13.1%, 10.7%, and 1.8% were from European, American, Western Pacific, Southeast Asian, and Eastern Mediterranean Regions. Most LT centers prioritized COVID-19 vaccine access for LT patients (76%) and healthcare workers (86%), while other categories had lower priority (30%). One-third of responders recommended mRNA vaccine exclusively, while booster doses were widely recommended (81%). One-third conducted post-vaccine liver function tests post COVID-19 vaccine. Only 16% of centers modified immunosuppression, and mycophenolate discontinuation or modification was the main approach. Side effects were seen in 1 in 1,000 vaccinated patients, with thromboembolism, acute rejection, and allergic reaction being the most severe. mRNA showed fewer side effects (−3.1, p = 0.002).ConclusionCOVID-19 vaccines and booster doses were widely used among LT recipients and healthcare workers, without a specific vaccine preference. Preventative immunosuppression adjustment post-vaccination was uncommon. mRNA vaccines demonstrated a favorable safety profile in this population. |
| first_indexed | 2024-03-08T13:03:19Z |
| format | Article |
| id | doaj.art-7c8f5113df6545fa80a85d96d1e01ad6 |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2024-03-08T13:03:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-7c8f5113df6545fa80a85d96d1e01ad62024-01-19T04:15:41ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402024-01-01210.3389/frtra.2023.13326161332616Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global surveyTommaso Di Maira0Tommaso Di Maira1Tommaso Di Maira2Carmen Vinaixa3Carmen Vinaixa4Carmen Vinaixa5Manhal Izzy6Francesco Paolo Russo7Varvara A. Kirchner8Ashwin Rammohan9Luca Saverio Belli10Wojciech Grzegorz Polak11Thomas Berg12Marina Berenguer13Marina Berenguer14Marina Berenguer15Liver Transplantation and Hepatology Unit, Hospital Universitari I Politècnic La Fe, Valencia, SpainBiomedical Research Network Center for Hepatic and Digestive Diseases (CIBEREHD), Madrid, SpainLa Fe Health Research Institute, Valencia, SpainLiver Transplantation and Hepatology Unit, Hospital Universitari I Politècnic La Fe, Valencia, SpainBiomedical Research Network Center for Hepatic and Digestive Diseases (CIBEREHD), Madrid, SpainLa Fe Health Research Institute, Valencia, SpainDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Surgery, Oncology and Gastroenterology, University Hospital Padua, Padua, ItalyDivision of Abdominal Transplantation, Department of Surgery, Stanford University, Stanford, CA, United StatesThe Institute of Liver Disease & Transplantation, Dr. Rela Institute & Medical Centre, Bharath Institute of Higher Education and Research, Chennai, IndiaDepartment of Hepatology and Gastroenterology, Niguarda Hospital, Milan, ItalyDepartment of Surgery, Division of HPB and Transplant Surgery, Erasmus MC Transplant Institute, University Medical Centre, Rotterdam, Netherlands0Division of Hepatology, Department of Medicine II, Leipzig University, Medical Center, Leipzig, GermanyLiver Transplantation and Hepatology Unit, Hospital Universitari I Politècnic La Fe, Valencia, SpainBiomedical Research Network Center for Hepatic and Digestive Diseases (CIBEREHD), Madrid, SpainLa Fe Health Research Institute, Valencia, SpainBackgroundDespite the WHO's report of 24 available SARS-CoV-2 vaccines, limited data exist regarding vaccination policies for liver transplant (LT) patients. To address this, we conducted a global multi-society survey (EASL-ESOT-ELITA-ILTS) in LT centers.MethodsA digital questionnaire assessing vaccine policies, safety, efficacy, and center data was administered online to LT centers.ResultsOut of 168 responding centers, 46.4%, 28%, 13.1%, 10.7%, and 1.8% were from European, American, Western Pacific, Southeast Asian, and Eastern Mediterranean Regions. Most LT centers prioritized COVID-19 vaccine access for LT patients (76%) and healthcare workers (86%), while other categories had lower priority (30%). One-third of responders recommended mRNA vaccine exclusively, while booster doses were widely recommended (81%). One-third conducted post-vaccine liver function tests post COVID-19 vaccine. Only 16% of centers modified immunosuppression, and mycophenolate discontinuation or modification was the main approach. Side effects were seen in 1 in 1,000 vaccinated patients, with thromboembolism, acute rejection, and allergic reaction being the most severe. mRNA showed fewer side effects (−3.1, p = 0.002).ConclusionCOVID-19 vaccines and booster doses were widely used among LT recipients and healthcare workers, without a specific vaccine preference. Preventative immunosuppression adjustment post-vaccination was uncommon. mRNA vaccines demonstrated a favorable safety profile in this population.https://www.frontiersin.org/articles/10.3389/frtra.2023.1332616/fullvaccineSARS-CoV-2livertransplantsurveypolicy |
| spellingShingle | Tommaso Di Maira Tommaso Di Maira Tommaso Di Maira Carmen Vinaixa Carmen Vinaixa Carmen Vinaixa Manhal Izzy Francesco Paolo Russo Varvara A. Kirchner Ashwin Rammohan Luca Saverio Belli Wojciech Grzegorz Polak Thomas Berg Marina Berenguer Marina Berenguer Marina Berenguer Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey Frontiers in Transplantation vaccine SARS-CoV-2 liver transplant survey policy |
| title | Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey |
| title_full | Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey |
| title_fullStr | Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey |
| title_full_unstemmed | Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey |
| title_short | Worldwide variations in COVID-19 vaccination policies and practices in liver transplant settings: results of a multi-society global survey |
| title_sort | worldwide variations in covid 19 vaccination policies and practices in liver transplant settings results of a multi society global survey |
| topic | vaccine SARS-CoV-2 liver transplant survey policy |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1332616/full |
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