Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain.
All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-04-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.2001573 |
| _version_ | 1818742505516040192 |
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| author | Beatriz Albuixech-Crespo Laura López-Blanch Demian Burguera Ignacio Maeso Luisa Sánchez-Arrones Juan Antonio Moreno-Bravo Ildiko Somorjai Juan Pascual-Anaya Eduardo Puelles Paola Bovolenta Jordi Garcia-Fernàndez Luis Puelles Manuel Irimia José Luis Ferran |
| author_facet | Beatriz Albuixech-Crespo Laura López-Blanch Demian Burguera Ignacio Maeso Luisa Sánchez-Arrones Juan Antonio Moreno-Bravo Ildiko Somorjai Juan Pascual-Anaya Eduardo Puelles Paola Bovolenta Jordi Garcia-Fernàndez Luis Puelles Manuel Irimia José Luis Ferran |
| author_sort | Beatriz Albuixech-Crespo |
| collection | DOAJ |
| description | All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice. |
| first_indexed | 2024-12-18T02:13:35Z |
| format | Article |
| id | doaj.art-7c920c7df9a0457f8e9590b239f9c7ec |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-18T02:13:35Z |
| publishDate | 2017-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-7c920c7df9a0457f8e9590b239f9c7ec2022-12-21T21:24:27ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852017-04-01154e200157310.1371/journal.pbio.2001573Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain.Beatriz Albuixech-CrespoLaura López-BlanchDemian BurgueraIgnacio MaesoLuisa Sánchez-ArronesJuan Antonio Moreno-BravoIldiko SomorjaiJuan Pascual-AnayaEduardo PuellesPaola BovolentaJordi Garcia-FernàndezLuis PuellesManuel IrimiaJosé Luis FerranAll vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.https://doi.org/10.1371/journal.pbio.2001573 |
| spellingShingle | Beatriz Albuixech-Crespo Laura López-Blanch Demian Burguera Ignacio Maeso Luisa Sánchez-Arrones Juan Antonio Moreno-Bravo Ildiko Somorjai Juan Pascual-Anaya Eduardo Puelles Paola Bovolenta Jordi Garcia-Fernàndez Luis Puelles Manuel Irimia José Luis Ferran Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology |
| title | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
| title_full | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
| title_fullStr | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
| title_full_unstemmed | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
| title_short | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
| title_sort | molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain |
| url | https://doi.org/10.1371/journal.pbio.2001573 |
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