Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial
Diabetes mellitus is an important issue for public health, and it is growing in the world. In recent years, there has been a growing research interest on efficacy evidence of the curcumin use in the regulation of glycemia and lipidaemia. The molecular structure of curcumins allows to intercept react...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/404 |
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| author | Emma Altobelli Paolo Matteo Angeletti Ciro Marziliano Marianna Mastrodomenico Anna Rita Giuliani Reimondo Petrocelli |
| author_facet | Emma Altobelli Paolo Matteo Angeletti Ciro Marziliano Marianna Mastrodomenico Anna Rita Giuliani Reimondo Petrocelli |
| author_sort | Emma Altobelli |
| collection | DOAJ |
| description | Diabetes mellitus is an important issue for public health, and it is growing in the world. In recent years, there has been a growing research interest on efficacy evidence of the curcumin use in the regulation of glycemia and lipidaemia. The molecular structure of curcumins allows to intercept reactive oxygen species (ROI) that are particularly harmful in chronic inflammation and tumorigenesis models. The aim of our study performed a systematic review and meta-analysis to evaluate the effect of curcumin on glycemic and lipid profile in subjects with uncomplicated type 2 diabetes. The papers included in the meta-analysis were sought in the MEDLINE, EMBASE, Scopus, Clinicaltrials.gov, Web of Science, and Cochrane Library databases as of October 2020. The sizes were pooled across studies in order to obtain an overall effect size. A random effects model was used to account for different sources of variation among studies. Cohen’s <i>d</i>, with 95% confidence interval (CI) was used as a measure of the effect size. Heterogeneity was assessed while using Q statistics. The ANOVA-Q test was used to value the differences among groups. Publication bias was analyzed and represented by a funnel plot. Curcumin treatment does not show a statistically significant reduction between treated and untreated patients. On the other hand, glycosylated hemoglobin, homeostasis model assessment (HOMA), and low-density lipoprotein (LDL) showed a statistically significant reduction in subjects that were treated with curcumin, respectively (<i>p</i> = 0.008, <i>p</i> < 0.001, <i>p</i> = 0.021). When considering HBA1c, the meta-regressions only showed statistical significance for gender (<i>p</i> = 0.034). Our meta-analysis seems to confirm the benefits on glucose metabolism, with results that appear to be more solid than those of lipid metabolism. However, further studies are needed in order to test the efficacy and safety of curcumin in uncomplicated type 2 diabetes. |
| first_indexed | 2024-03-09T03:29:32Z |
| format | Article |
| id | doaj.art-7c96c9f65550454abc2fd4a8a539ae56 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:29:32Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7c96c9f65550454abc2fd4a8a539ae562023-12-03T14:57:25ZengMDPI AGNutrients2072-66432021-01-0113240410.3390/nu13020404Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled TrialEmma Altobelli0Paolo Matteo Angeletti1Ciro Marziliano2Marianna Mastrodomenico3Anna Rita Giuliani4Reimondo Petrocelli5Department of Life, Public Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Public Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Public Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Public Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Public Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyPublic Health Unit, ASREM, 86100 Campobasso, ItalyDiabetes mellitus is an important issue for public health, and it is growing in the world. In recent years, there has been a growing research interest on efficacy evidence of the curcumin use in the regulation of glycemia and lipidaemia. The molecular structure of curcumins allows to intercept reactive oxygen species (ROI) that are particularly harmful in chronic inflammation and tumorigenesis models. The aim of our study performed a systematic review and meta-analysis to evaluate the effect of curcumin on glycemic and lipid profile in subjects with uncomplicated type 2 diabetes. The papers included in the meta-analysis were sought in the MEDLINE, EMBASE, Scopus, Clinicaltrials.gov, Web of Science, and Cochrane Library databases as of October 2020. The sizes were pooled across studies in order to obtain an overall effect size. A random effects model was used to account for different sources of variation among studies. Cohen’s <i>d</i>, with 95% confidence interval (CI) was used as a measure of the effect size. Heterogeneity was assessed while using Q statistics. The ANOVA-Q test was used to value the differences among groups. Publication bias was analyzed and represented by a funnel plot. Curcumin treatment does not show a statistically significant reduction between treated and untreated patients. On the other hand, glycosylated hemoglobin, homeostasis model assessment (HOMA), and low-density lipoprotein (LDL) showed a statistically significant reduction in subjects that were treated with curcumin, respectively (<i>p</i> = 0.008, <i>p</i> < 0.001, <i>p</i> = 0.021). When considering HBA1c, the meta-regressions only showed statistical significance for gender (<i>p</i> = 0.034). Our meta-analysis seems to confirm the benefits on glucose metabolism, with results that appear to be more solid than those of lipid metabolism. However, further studies are needed in order to test the efficacy and safety of curcumin in uncomplicated type 2 diabetes.https://www.mdpi.com/2072-6643/13/2/404curcumaturmerictype 2 diabetesdyslipidemiameta-analysisrandomized control trial |
| spellingShingle | Emma Altobelli Paolo Matteo Angeletti Ciro Marziliano Marianna Mastrodomenico Anna Rita Giuliani Reimondo Petrocelli Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial Nutrients curcuma turmeric type 2 diabetes dyslipidemia meta-analysis randomized control trial |
| title | Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial |
| title_full | Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial |
| title_fullStr | Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial |
| title_full_unstemmed | Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial |
| title_short | Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes—A Meta-Analysis of Randomized Controlled Trial |
| title_sort | potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes a meta analysis of randomized controlled trial |
| topic | curcuma turmeric type 2 diabetes dyslipidemia meta-analysis randomized control trial |
| url | https://www.mdpi.com/2072-6643/13/2/404 |
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