Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure
Congestive heart failure (CHF), the leading cause of death, is deemed a grave sequel of myocardial infarction (MI). The employment of left ventricular end-diastolic pressure (LVEDP), as a primary indication of CHF, becomes restricted owing to the potential impairment of heart function and caused inj...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.944171/full |
| _version_ | 1811321281892581376 |
|---|---|
| author | Hussein M. El-Husseiny Hussein M. El-Husseiny Eman A. Mady Eman A. Mady Danfu Ma Danfu Ma Lina Hamabe Ken Takahashi Ryou Tanaka |
| author_facet | Hussein M. El-Husseiny Hussein M. El-Husseiny Eman A. Mady Eman A. Mady Danfu Ma Danfu Ma Lina Hamabe Ken Takahashi Ryou Tanaka |
| author_sort | Hussein M. El-Husseiny |
| collection | DOAJ |
| description | Congestive heart failure (CHF), the leading cause of death, is deemed a grave sequel of myocardial infarction (MI). The employment of left ventricular end-diastolic pressure (LVEDP), as a primary indication of CHF, becomes restricted owing to the potential impairment of heart function and caused injury to the aortic valve during its measurement. Echocardiography is the standard technique to detect cardiac dysfunction. However, it exhibits a low capacity to predict the progression of CHF post chronic MI. Being extremely sensitive, noninvasive, and preload-independent, intraventricular pressure gradient (IVPG) was lately introduced to evaluate cardiac function, specifically during cardiomyopathy. Yet, the utility of its use to assess the CHF progression after chronic MI was not investigated. Herein, in the current research, we aimed to study the efficacy of a novel echocardiographic-derived index as IVPG in the assessment of cardiac function in a chronic MI rat model with CHF. Fifty healthy male rats were involved, and MI was surgically induced in 35 of them. Six months post-surgery, all animals were examined using transthoracic conventional and color M-mode echocardiography (CMME) for IVPG. Animals were euthanized the following day after hemodynamics recording. Gross pathological and histological evaluations were performed. J-tree cluster analysis was conducted relying on ten echocardiographic parameters suggestive of CHF. Animals were merged into two main clusters: CHF+ (MI/HF + group, n = 22) and CHF– (n = 28) that was joined from Sham (n = 15), and MI/HF– (n = 13) groups. MI/HF+ group showed the most severe echocardiographic, hemodynamic, anatomic, and histologic alterations. There was no significant change in the total IVPG among various groups. However, the basal IVPG was significantly increased in MI/HF+ group compared to the other groups. The remaining IVPG measures were considerably increased in the MI/HF+ group than in the Sham one. The segmental IVPG measures were significantly correlated with the anatomical, histological, echocardiographic, and hemodynamic findings except for the heart rate. Moreover, they were significant predictors of CHF following a long-standing MI. Conclusively, IVPG obtained from CMME is a substantially promising noninvasive tool with a high ability to detect and predict the progression of CHF following chronic MI compared to conventional echocardiography. |
| first_indexed | 2024-04-13T13:14:06Z |
| format | Article |
| id | doaj.art-7c96f93e40594b74a8054ede2277947a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T13:14:06Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7c96f93e40594b74a8054ede2277947a2022-12-22T02:45:31ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.944171944171Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failureHussein M. El-Husseiny0Hussein M. El-Husseiny1Eman A. Mady2Eman A. Mady3Danfu Ma4Danfu Ma5Lina Hamabe6Ken Takahashi7Ryou Tanaka8Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanDepartment of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Toukh, EgyptLaboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanDepartment of Animal Hygiene, Behavior and Management, Faculty of Veterinary Medicine, Benha University, Toukh, EgyptLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, ChinaLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Bunkyo, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanCongestive heart failure (CHF), the leading cause of death, is deemed a grave sequel of myocardial infarction (MI). The employment of left ventricular end-diastolic pressure (LVEDP), as a primary indication of CHF, becomes restricted owing to the potential impairment of heart function and caused injury to the aortic valve during its measurement. Echocardiography is the standard technique to detect cardiac dysfunction. However, it exhibits a low capacity to predict the progression of CHF post chronic MI. Being extremely sensitive, noninvasive, and preload-independent, intraventricular pressure gradient (IVPG) was lately introduced to evaluate cardiac function, specifically during cardiomyopathy. Yet, the utility of its use to assess the CHF progression after chronic MI was not investigated. Herein, in the current research, we aimed to study the efficacy of a novel echocardiographic-derived index as IVPG in the assessment of cardiac function in a chronic MI rat model with CHF. Fifty healthy male rats were involved, and MI was surgically induced in 35 of them. Six months post-surgery, all animals were examined using transthoracic conventional and color M-mode echocardiography (CMME) for IVPG. Animals were euthanized the following day after hemodynamics recording. Gross pathological and histological evaluations were performed. J-tree cluster analysis was conducted relying on ten echocardiographic parameters suggestive of CHF. Animals were merged into two main clusters: CHF+ (MI/HF + group, n = 22) and CHF– (n = 28) that was joined from Sham (n = 15), and MI/HF– (n = 13) groups. MI/HF+ group showed the most severe echocardiographic, hemodynamic, anatomic, and histologic alterations. There was no significant change in the total IVPG among various groups. However, the basal IVPG was significantly increased in MI/HF+ group compared to the other groups. The remaining IVPG measures were considerably increased in the MI/HF+ group than in the Sham one. The segmental IVPG measures were significantly correlated with the anatomical, histological, echocardiographic, and hemodynamic findings except for the heart rate. Moreover, they were significant predictors of CHF following a long-standing MI. Conclusively, IVPG obtained from CMME is a substantially promising noninvasive tool with a high ability to detect and predict the progression of CHF following chronic MI compared to conventional echocardiography.https://www.frontiersin.org/articles/10.3389/fcvm.2022.944171/fullintraventricular pressure gradientIVPGcongestive heart failuremyocardial infarctiondiastolic dysfunctionechocardiography |
| spellingShingle | Hussein M. El-Husseiny Hussein M. El-Husseiny Eman A. Mady Eman A. Mady Danfu Ma Danfu Ma Lina Hamabe Ken Takahashi Ryou Tanaka Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure Frontiers in Cardiovascular Medicine intraventricular pressure gradient IVPG congestive heart failure myocardial infarction diastolic dysfunction echocardiography |
| title | Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure |
| title_full | Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure |
| title_fullStr | Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure |
| title_full_unstemmed | Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure |
| title_short | Intraventricular pressure gradient: A novel tool to assess the post-infarction chronic congestive heart failure |
| title_sort | intraventricular pressure gradient a novel tool to assess the post infarction chronic congestive heart failure |
| topic | intraventricular pressure gradient IVPG congestive heart failure myocardial infarction diastolic dysfunction echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.944171/full |
| work_keys_str_mv | AT husseinmelhusseiny intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT husseinmelhusseiny intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT emanamady intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT emanamady intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT danfuma intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT danfuma intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT linahamabe intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT kentakahashi intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure AT ryoutanaka intraventricularpressuregradientanoveltooltoassessthepostinfarctionchroniccongestiveheartfailure |