SAWAR DARAH OTAK
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| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Udayana
2013-09-01
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| Series: | e-Jurnal Medika Udayana |
| Subjects: | |
| Online Access: | http://ojs.unud.ac.id/index.php/eum/article/view/6293 |
| _version_ | 1819084195474964480 |
|---|---|
| author | Aluh Sri Yuliana Ulfa Tjok Gde Bagus Mahadewa |
| author_facet | Aluh Sri Yuliana Ulfa Tjok Gde Bagus Mahadewa |
| author_sort | Aluh Sri Yuliana Ulfa |
| collection | DOAJ |
| description | <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNoSpacing" style="text-align: justify;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif";">The Blood–Brain Barrier (BBB) is a separation of circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). It is a physical barrier between the local blood vessels and most parts of the central nervous system itself, and stops many substances from travelling across it. The BBB is permeable to alcohol, and some heavy metals can cross the blood-brain barrier as well. The concept of the blood brain barrier was first introduced by Paul Ehrlich.<span style="mso-spacerun: yes;"> </span>He found that intravenous injection of dyes into the bloodstream stained all the tissues in most organs except the brain.<span style="mso-spacerun: yes;"> </span>Using electron microscopy and electron- dense tracers such as horseradish peroxidase (HRP) a group of scientists demonstrated that the blood- brain barrier is located in endothelial cells of capillaries of the brain.The BBB is to protecting the brain internally as the skull is to protecting it externally.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 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| first_indexed | 2024-12-21T20:44:36Z |
| format | Article |
| id | doaj.art-7c96fe053b75478798bab6647c460784 |
| institution | Directory Open Access Journal |
| issn | 2303-1395 |
| language | English |
| last_indexed | 2024-12-21T20:44:36Z |
| publishDate | 2013-09-01 |
| publisher | Universitas Udayana |
| record_format | Article |
| series | e-Jurnal Medika Udayana |
| spelling | doaj.art-7c96fe053b75478798bab6647c4607842022-12-21T18:50:51ZengUniversitas Udayanae-Jurnal Medika Udayana2303-13952013-09-0129148915105717SAWAR DARAH OTAKAluh Sri Yuliana UlfaTjok Gde Bagus Mahadewa<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNoSpacing" style="text-align: justify;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif";">The Blood–Brain Barrier (BBB) is a separation of circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). It is a physical barrier between the local blood vessels and most parts of the central nervous system itself, and stops many substances from travelling across it. The BBB is permeable to alcohol, and some heavy metals can cross the blood-brain barrier as well. The concept of the blood brain barrier was first introduced by Paul Ehrlich.<span style="mso-spacerun: yes;"> </span>He found that intravenous injection of dyes into the bloodstream stained all the tissues in most organs except the brain.<span style="mso-spacerun: yes;"> </span>Using electron microscopy and electron- dense tracers such as horseradish peroxidase (HRP) a group of scientists demonstrated that the blood- brain barrier is located in endothelial cells of capillaries of the brain.The BBB is to protecting the brain internally as the skull is to protecting it externally.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 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| spellingShingle | Aluh Sri Yuliana Ulfa Tjok Gde Bagus Mahadewa SAWAR DARAH OTAK e-Jurnal Medika Udayana Blood–Brain Barrier, Central Nervous System |
| title | SAWAR DARAH OTAK |
| title_full | SAWAR DARAH OTAK |
| title_fullStr | SAWAR DARAH OTAK |
| title_full_unstemmed | SAWAR DARAH OTAK |
| title_short | SAWAR DARAH OTAK |
| title_sort | sawar darah otak |
| topic | Blood–Brain Barrier, Central Nervous System |
| url | http://ojs.unud.ac.id/index.php/eum/article/view/6293 |
| work_keys_str_mv | AT aluhsriyulianaulfa sawardarahotak AT tjokgdebagusmahadewa sawardarahotak |