Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Activated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice. How the detection of prolonged activated aPTT with a normal prothrombin time is interpreted is therefore very important. In daily p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/6/1169 |
| _version_ | 1827736481356054528 |
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| author | Rita Carlotta Santoro Angelo Claudio Molinari Marzia Leotta Tiziano Martini |
| author_facet | Rita Carlotta Santoro Angelo Claudio Molinari Marzia Leotta Tiziano Martini |
| author_sort | Rita Carlotta Santoro |
| collection | DOAJ |
| description | Activated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice. How the detection of prolonged activated aPTT with a normal prothrombin time is interpreted is therefore very important. In daily practice, the detection of this abnormality often leads to delayed surgery and emotional stress for patients and their families and may be associated with increased costs due to re-testing and coagulation factor assessment. An isolated, prolonged aPTT is seen in (a) patients with congenital or acquired deficiencies of specific coagulation factors, (b) patients receiving treatment with anticoagulants, mainly heparin, and (c) individuals/patients with circulating anticoagulants. We summarize here what may cause an isolated prolonged aPTT and evaluate the preanalytical interferences. The identification of the cause of an isolated prolonged aPTT is of the utmost importance in ensuring the correct diagnostic workup and therapeutic choices. |
| first_indexed | 2024-03-11T02:10:28Z |
| format | Article |
| id | doaj.art-7c9805e1eaff4234987448d54c96fefc |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T02:10:28Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-7c9805e1eaff4234987448d54c96fefc2023-11-18T11:32:29ZengMDPI AGMedicina1010-660X1648-91442023-06-01596116910.3390/medicina59061169Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!Rita Carlotta Santoro0Angelo Claudio Molinari1Marzia Leotta2Tiziano Martini3Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, 88100 Catanzaro, ItalyThrombosis and Hemostasis Unit, IRCCS Istituto Giannina Gaslini, 16147 Genova, ItalyHemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, 88100 Catanzaro, ItalyImmuno-Haematology and Transfusion Medicine, Center for Congenital Bleeding Disorders, Cesena General Hospital, 47521 Cesena, ItalyActivated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice. How the detection of prolonged activated aPTT with a normal prothrombin time is interpreted is therefore very important. In daily practice, the detection of this abnormality often leads to delayed surgery and emotional stress for patients and their families and may be associated with increased costs due to re-testing and coagulation factor assessment. An isolated, prolonged aPTT is seen in (a) patients with congenital or acquired deficiencies of specific coagulation factors, (b) patients receiving treatment with anticoagulants, mainly heparin, and (c) individuals/patients with circulating anticoagulants. We summarize here what may cause an isolated prolonged aPTT and evaluate the preanalytical interferences. The identification of the cause of an isolated prolonged aPTT is of the utmost importance in ensuring the correct diagnostic workup and therapeutic choices.https://www.mdpi.com/1648-9144/59/6/1169activated partial thromboplastin time (aPTT)coagulation factor defectmixing testintrinsic pathwaycirculating anticoagulantsbleeding patient |
| spellingShingle | Rita Carlotta Santoro Angelo Claudio Molinari Marzia Leotta Tiziano Martini Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! Medicina activated partial thromboplastin time (aPTT) coagulation factor defect mixing test intrinsic pathway circulating anticoagulants bleeding patient |
| title | Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! |
| title_full | Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! |
| title_fullStr | Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! |
| title_full_unstemmed | Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! |
| title_short | Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk! |
| title_sort | isolated prolongation of activated partial thromboplastin time not just bleeding risk |
| topic | activated partial thromboplastin time (aPTT) coagulation factor defect mixing test intrinsic pathway circulating anticoagulants bleeding patient |
| url | https://www.mdpi.com/1648-9144/59/6/1169 |
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