A review of the role and mechanisms of action of baclofen in the management of central hyperthermia
Baclofen was previously known for its efficacy to treat spasticity but this agent has been studied and reported to have several other uses including its role in central hyperthermia. Central hyperthermia is associated with increased morbidity, mortality, and the impact of neuronal damage on the cent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-04.pdf |
| _version_ | 1817988176941154304 |
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| author | I Wayan Widyantara Valentina Tjandra Dewi |
| author_facet | I Wayan Widyantara Valentina Tjandra Dewi |
| author_sort | I Wayan Widyantara |
| collection | DOAJ |
| description | Baclofen was previously known for its efficacy to treat spasticity but this agent has been studied and reported to have several other uses including its role in central hyperthermia. Central hyperthermia is associated with increased morbidity, mortality, and the impact of neuronal damage on the central nervous system. Until now there is no established guideline for the management of central hyperthermia which generally does not respond to standard antipyretic therapy. In this literature review, we will discuss the basic concepts of central hyperthermia and the role and mechanism of action of baclofen as an option for central hyperthermia therapy. |
| first_indexed | 2024-04-14T00:31:05Z |
| format | Article |
| id | doaj.art-7c98a1fe13cd4c1289ad910ca4722c8d |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-14T00:31:05Z |
| publishDate | 2021-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-7c98a1fe13cd4c1289ad910ca4722c8d2022-12-22T02:22:32ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942021-12-0120443443710.37897/RJN.2021.4.4A review of the role and mechanisms of action of baclofen in the management of central hyperthermiaI Wayan Widyantara0Valentina Tjandra Dewi1Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, IndonesiaBaclofen was previously known for its efficacy to treat spasticity but this agent has been studied and reported to have several other uses including its role in central hyperthermia. Central hyperthermia is associated with increased morbidity, mortality, and the impact of neuronal damage on the central nervous system. Until now there is no established guideline for the management of central hyperthermia which generally does not respond to standard antipyretic therapy. In this literature review, we will discuss the basic concepts of central hyperthermia and the role and mechanism of action of baclofen as an option for central hyperthermia therapy.https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-04.pdfbaclofencentral hyperthermiamanagementmechanism |
| spellingShingle | I Wayan Widyantara Valentina Tjandra Dewi A review of the role and mechanisms of action of baclofen in the management of central hyperthermia Romanian Journal of Neurology baclofen central hyperthermia management mechanism |
| title | A review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| title_full | A review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| title_fullStr | A review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| title_full_unstemmed | A review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| title_short | A review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| title_sort | review of the role and mechanisms of action of baclofen in the management of central hyperthermia |
| topic | baclofen central hyperthermia management mechanism |
| url | https://rjn.com.ro/articles/2021.4/RJN_2021_4_Art-04.pdf |
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