Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions

Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions

The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound. A total of 30% Fenofibrate-loaded mesoporous silica and s...

Full description

Bibliographic Details
Main Authors: Hongwei Zhang, Minglu Li, Jianmin Li, Anjali Agrawal, Ho-Wah Hui, Demin Liu
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
mesoporous silica
fenofibrate
spray-dried solid dispersions
stability
manufacturability
in vitro 2-stage dissolution
Online Access:https://www.mdpi.com/1999-4923/14/2/428

Internet

https://www.mdpi.com/1999-4923/14/2/428

Similar Items