Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study
Purpose: This study explores the association between alveolar bone loss, tooth loss and severity of COVID-19. Materials and methods: In this retrospective cohort study, we included patients with confirmed COVID-19 who have had a dental panoramic radiograph within a maximum period of 5 years, providi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | Advances in Oral and Maxillofacial Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667147621002120 |
| _version_ | 1818300020670070784 |
|---|---|
| author | H.C.M. Donders J.M. van der Sleen Y.J. Kleinbergen N. Su J. de Lange B.G. Loos |
| author_facet | H.C.M. Donders J.M. van der Sleen Y.J. Kleinbergen N. Su J. de Lange B.G. Loos |
| author_sort | H.C.M. Donders |
| collection | DOAJ |
| description | Purpose: This study explores the association between alveolar bone loss, tooth loss and severity of COVID-19. Materials and methods: In this retrospective cohort study, we included patients with confirmed COVID-19 who have had a dental panoramic radiograph within a maximum period of 5 years, providing information about alveolar bone loss and tooth loss. The severity of COVID-19 was determined based on the WHO clinical progression scale: (1) Mild/Ambulatory; (2) Moderate/Hospitalized; (3) Severe/Intensive care unit (ICU) or death. Results: 1730 patients were identified with COVID-19 from until October 31, 2020 in the Isala Hospital. Of these patients, 389 ever visited the OMFS department. 133 patients have had an orthopantomograph within a maximum period of 5 years and were included for analysis. The results showed a significant association between alveolar bone loss and COVID-19 severity (p = 0.028). Patients with alveolar bone loss had 5.6 times higher odds to be admitted to ICU or died, compared to ambulatory patients (OR: 5.60; 95%CI: 1.21; 25.99; P = 0.028). More tooth loss was significantly associated with COVID-19 severity (p = 0.047). Per tooth lost, patients had 4.2% higher odds for severe than mild COVID-19 (OR: 1.04; 95%CI: 1.00; 1.09; P = 0.047) and 6.0% higher odds for severe than moderate COVID-19 (OR: 1.06; 95%CI: 1.01; 1.11; P = 0.017). When adjusting for confounders in multivariate analyses, the significant associations of COVID-19 with alveolar bone loss and tooth loss were no longer present. Conclusion: In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors. The current study could contribute to the design of further studies on the relationship between oral health and COVID-19. |
| first_indexed | 2024-12-13T05:00:29Z |
| format | Article |
| id | doaj.art-7c9d5e0927794718a8a5daa663285802 |
| institution | Directory Open Access Journal |
| issn | 2667-1476 |
| language | English |
| last_indexed | 2024-12-13T05:00:29Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Oral and Maxillofacial Surgery |
| spelling | doaj.art-7c9d5e0927794718a8a5daa6632858022022-12-21T23:58:48ZengElsevierAdvances in Oral and Maxillofacial Surgery2667-14762022-01-015100223Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative studyH.C.M. Donders0J.M. van der Sleen1Y.J. Kleinbergen2N. Su3J. de Lange4B.G. Loos5Department of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Isala, Zwolle, the Netherlands; Corresponding author. Department of Oral and Maxillofacial Surgery, Isala, Dokter van Heesweg 2, 8025, AB, Zwolle, the Netherlands. Tel.: +31 38 4242881.Department of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Isala, Zwolle, the NetherlandsDepartment of Oral and Maxillofacial Surgery, Isala, Zwolle, the NetherlandsDepartment of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Social Dentistry, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, the NetherlandsDepartment of Oral and Maxillofacial Surgery, Amsterdam UMC, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Isala, Zwolle, the NetherlandsDepartment of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, the NetherlandsPurpose: This study explores the association between alveolar bone loss, tooth loss and severity of COVID-19. Materials and methods: In this retrospective cohort study, we included patients with confirmed COVID-19 who have had a dental panoramic radiograph within a maximum period of 5 years, providing information about alveolar bone loss and tooth loss. The severity of COVID-19 was determined based on the WHO clinical progression scale: (1) Mild/Ambulatory; (2) Moderate/Hospitalized; (3) Severe/Intensive care unit (ICU) or death. Results: 1730 patients were identified with COVID-19 from until October 31, 2020 in the Isala Hospital. Of these patients, 389 ever visited the OMFS department. 133 patients have had an orthopantomograph within a maximum period of 5 years and were included for analysis. The results showed a significant association between alveolar bone loss and COVID-19 severity (p = 0.028). Patients with alveolar bone loss had 5.6 times higher odds to be admitted to ICU or died, compared to ambulatory patients (OR: 5.60; 95%CI: 1.21; 25.99; P = 0.028). More tooth loss was significantly associated with COVID-19 severity (p = 0.047). Per tooth lost, patients had 4.2% higher odds for severe than mild COVID-19 (OR: 1.04; 95%CI: 1.00; 1.09; P = 0.047) and 6.0% higher odds for severe than moderate COVID-19 (OR: 1.06; 95%CI: 1.01; 1.11; P = 0.017). When adjusting for confounders in multivariate analyses, the significant associations of COVID-19 with alveolar bone loss and tooth loss were no longer present. Conclusion: In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors. The current study could contribute to the design of further studies on the relationship between oral health and COVID-19.http://www.sciencedirect.com/science/article/pii/S2667147621002120COVID19Tooth lossPeriodontitis |
| spellingShingle | H.C.M. Donders J.M. van der Sleen Y.J. Kleinbergen N. Su J. de Lange B.G. Loos Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study Advances in Oral and Maxillofacial Surgery COVID19 Tooth loss Periodontitis |
| title | Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study |
| title_full | Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study |
| title_fullStr | Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study |
| title_full_unstemmed | Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study |
| title_short | Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study |
| title_sort | alveolar bone loss and tooth loss are associated with covid 19 severity but are not independent risk factors an explorative study |
| topic | COVID19 Tooth loss Periodontitis |
| url | http://www.sciencedirect.com/science/article/pii/S2667147621002120 |
| work_keys_str_mv | AT hcmdonders alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy AT jmvandersleen alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy AT yjkleinbergen alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy AT nsu alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy AT jdelange alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy AT bgloos alveolarbonelossandtoothlossareassociatedwithcovid19severitybutarenotindependentriskfactorsanexplorativestudy |