Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level.
The present study evaluated the relative influence of body mass index (BMI) on insulin resistance (IR), first-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and glucose effectiveness (GE) at a fixed fasting plasma glucose level in an older ethnic Chinese population.In total,...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5788342?pdf=render |
| _version_ | 1818290299700510720 |
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| author | Jiunn-Diann Lin Chun-Hsien Hsu Chung-Ze Wu An-Tsz Hsieh Chang-Hsun Hsieh Yao-Jen Liang Yen-Lin Chen Dee Pei Jin-Biou Chang |
| author_facet | Jiunn-Diann Lin Chun-Hsien Hsu Chung-Ze Wu An-Tsz Hsieh Chang-Hsun Hsieh Yao-Jen Liang Yen-Lin Chen Dee Pei Jin-Biou Chang |
| author_sort | Jiunn-Diann Lin |
| collection | DOAJ |
| description | The present study evaluated the relative influence of body mass index (BMI) on insulin resistance (IR), first-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and glucose effectiveness (GE) at a fixed fasting plasma glucose level in an older ethnic Chinese population.In total, 265 individuals aged 60 years with a fasting plasma glucose level of 5.56 mmol/L were enrolled. Participants had BMIs of 20.0-34.2 kg/m2. IR, FPIS, SPIS, and GE were estimated using our previously developed equations. Pearson correlation analysis was conducted to assess the correlations between the four diabetogenesis factors and BMI. A general linear model was used to determine the differences in the percentage of change among the four factor slopes against BMI.Significant correlations were observed between BMI and FPIS, SPIS, IR, and GE in both women and men, which were higher than those reported previously. In men, BMI had the most profound effect on SPIS, followed by IR, FPIS, and GE, whereas in women, the order was slightly different: IR, followed by FPIS, SPIS, and GE. Significant differences were observed among all these slopes, except for the slopes between FPIS and SPIS in women (p = 0.856) and IR and FPIS in men (p = 0.258).The contribution of obesity to all diabetes factors, except GE, was higher than that reported previously. BMI had the most profound effect on insulin secretion in men and on IR in women in this 60-year-old cohort, suggesting that lifestyle modifications for obesity reduction in women remain the most important method for improving glucose metabolism and preventing future type 2 diabetes mellitus. |
| first_indexed | 2024-12-13T02:25:58Z |
| format | Article |
| id | doaj.art-7c9d796abff948158b6819bffab3d360 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:25:58Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7c9d796abff948158b6819bffab3d3602022-12-22T00:02:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01131e018911510.1371/journal.pone.0189115Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level.Jiunn-Diann LinChun-Hsien HsuChung-Ze WuAn-Tsz HsiehChang-Hsun HsiehYao-Jen LiangYen-Lin ChenDee PeiJin-Biou ChangThe present study evaluated the relative influence of body mass index (BMI) on insulin resistance (IR), first-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and glucose effectiveness (GE) at a fixed fasting plasma glucose level in an older ethnic Chinese population.In total, 265 individuals aged 60 years with a fasting plasma glucose level of 5.56 mmol/L were enrolled. Participants had BMIs of 20.0-34.2 kg/m2. IR, FPIS, SPIS, and GE were estimated using our previously developed equations. Pearson correlation analysis was conducted to assess the correlations between the four diabetogenesis factors and BMI. A general linear model was used to determine the differences in the percentage of change among the four factor slopes against BMI.Significant correlations were observed between BMI and FPIS, SPIS, IR, and GE in both women and men, which were higher than those reported previously. In men, BMI had the most profound effect on SPIS, followed by IR, FPIS, and GE, whereas in women, the order was slightly different: IR, followed by FPIS, SPIS, and GE. Significant differences were observed among all these slopes, except for the slopes between FPIS and SPIS in women (p = 0.856) and IR and FPIS in men (p = 0.258).The contribution of obesity to all diabetes factors, except GE, was higher than that reported previously. BMI had the most profound effect on insulin secretion in men and on IR in women in this 60-year-old cohort, suggesting that lifestyle modifications for obesity reduction in women remain the most important method for improving glucose metabolism and preventing future type 2 diabetes mellitus.http://europepmc.org/articles/PMC5788342?pdf=render |
| spellingShingle | Jiunn-Diann Lin Chun-Hsien Hsu Chung-Ze Wu An-Tsz Hsieh Chang-Hsun Hsieh Yao-Jen Liang Yen-Lin Chen Dee Pei Jin-Biou Chang Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. PLoS ONE |
| title | Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. |
| title_full | Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. |
| title_fullStr | Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. |
| title_full_unstemmed | Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. |
| title_short | Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level. |
| title_sort | effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level |
| url | http://europepmc.org/articles/PMC5788342?pdf=render |
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