Synthesis and biological activity of some triazole-bearing benzimidazole derivatives
A number of N’-(arylmethylidene)-2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide and 4-aryl-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4H-1,2,4-triazole-3-thiol derivatives were synthesized by incorporating various aromatic and heterocyclic substituents on 2-methyl-1H-benzimidazole. The structures of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2011-03-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.rs/JSCS/Vol76/No3/03_4708_4122.pdf |
| _version_ | 1811297956486184960 |
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| author | K. F. ANSAR C. LAL R. K. KHITOLIYA |
| author_facet | K. F. ANSAR C. LAL R. K. KHITOLIYA |
| author_sort | K. F. ANSAR |
| collection | DOAJ |
| description | A number of N’-(arylmethylidene)-2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide and 4-aryl-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4H-1,2,4-triazole-3-thiol derivatives were synthesized by incorporating various aromatic and heterocyclic substituents on 2-methyl-1H-benzimidazole. The structures of all the synthesized compounds were elucidated based on their elemental analyses and spectral data. The in vitro activities of these compounds against bacteria and fungi were evaluated by the disc diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found to be as active as kanamycin (standard drug). |
| first_indexed | 2024-04-13T06:12:47Z |
| format | Article |
| id | doaj.art-7c9e22ba8cb6485c8a3fd95f34086a52 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-04-13T06:12:47Z |
| publishDate | 2011-03-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-7c9e22ba8cb6485c8a3fd95f34086a522022-12-22T02:58:57ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392011-03-01763341352Synthesis and biological activity of some triazole-bearing benzimidazole derivativesK. F. ANSARC. LALR. K. KHITOLIYAA number of N’-(arylmethylidene)-2-(2-methyl-1H-benzimidazol-1-yl)acetohydrazide and 4-aryl-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4H-1,2,4-triazole-3-thiol derivatives were synthesized by incorporating various aromatic and heterocyclic substituents on 2-methyl-1H-benzimidazole. The structures of all the synthesized compounds were elucidated based on their elemental analyses and spectral data. The in vitro activities of these compounds against bacteria and fungi were evaluated by the disc diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found to be as active as kanamycin (standard drug).http://www.shd.org.rs/JSCS/Vol76/No3/03_4708_4122.pdfbenzimidazoletriazoleantimicrobial activityampicillinkanamycinamphotericin B |
| spellingShingle | K. F. ANSAR C. LAL R. K. KHITOLIYA Synthesis and biological activity of some triazole-bearing benzimidazole derivatives Journal of the Serbian Chemical Society benzimidazole triazole antimicrobial activity ampicillin kanamycin amphotericin B |
| title | Synthesis and biological activity of some triazole-bearing benzimidazole derivatives |
| title_full | Synthesis and biological activity of some triazole-bearing benzimidazole derivatives |
| title_fullStr | Synthesis and biological activity of some triazole-bearing benzimidazole derivatives |
| title_full_unstemmed | Synthesis and biological activity of some triazole-bearing benzimidazole derivatives |
| title_short | Synthesis and biological activity of some triazole-bearing benzimidazole derivatives |
| title_sort | synthesis and biological activity of some triazole bearing benzimidazole derivatives |
| topic | benzimidazole triazole antimicrobial activity ampicillin kanamycin amphotericin B |
| url | http://www.shd.org.rs/JSCS/Vol76/No3/03_4708_4122.pdf |
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