The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy
Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy). Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matche...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Journal of Retina
2019-02-01
|
| Series: | IJRETINA (International Journal of Retina) |
| Online Access: | https://www.ijretina.com/index.php/ijretina/article/view/53 |
| _version_ | 1818875035584036864 |
|---|---|
| author | Anna Nur Utami Elvioza Elvioza M Sidik |
| author_facet | Anna Nur Utami Elvioza Elvioza M Sidik |
| author_sort | Anna Nur Utami |
| collection | DOAJ |
| description | Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy).
Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR). In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment.
Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45.
Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35). |
| first_indexed | 2024-12-19T13:20:06Z |
| format | Article |
| id | doaj.art-7c9edfdffb514e07b8c55209296bbd30 |
| institution | Directory Open Access Journal |
| issn | 2614-8684 2614-8536 |
| language | English |
| last_indexed | 2024-12-19T13:20:06Z |
| publishDate | 2019-02-01 |
| publisher | International Journal of Retina |
| record_format | Article |
| series | IJRETINA (International Journal of Retina) |
| spelling | doaj.art-7c9edfdffb514e07b8c55209296bbd302022-12-21T20:19:44ZengInternational Journal of RetinaIJRETINA (International Journal of Retina)2614-86842614-85362019-02-012153The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic RetinopathyAnna Nur Utami0Elvioza Elvioza1M SidikJakarta Eye CentreJakarta Eye CentreIntroduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy). Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR). In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment. Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45. Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).https://www.ijretina.com/index.php/ijretina/article/view/53 |
| spellingShingle | Anna Nur Utami Elvioza Elvioza M Sidik The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy IJRETINA (International Journal of Retina) |
| title | The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy |
| title_full | The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy |
| title_fullStr | The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy |
| title_full_unstemmed | The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy |
| title_short | The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy |
| title_sort | effect of citicoline on electroretinography abnormalities in patients with non proliferative diabetic retinopathy |
| url | https://www.ijretina.com/index.php/ijretina/article/view/53 |
| work_keys_str_mv | AT annanurutami theeffectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy AT elviozaelvioza theeffectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy AT msidik theeffectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy AT annanurutami effectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy AT elviozaelvioza effectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy AT msidik effectofciticolineonelectroretinographyabnormalitiesinpatientswithnonproliferativediabeticretinopathy |