UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis
In the present article it is described the validation of a simple, precise, accurate, rapid and low-cost UV spectrophotometric method for quantification of paracetamol in tablets. The method was linear in the range between 6.4 - 9.6 μg mL-1, presenting a good correlation coefficient (r = 0.9984) and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Mato Grosso do Sul
2018-12-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/16037 |
| _version_ | 1797946847707267072 |
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| author | Enock José Alves Goes Junior Jakson Santos Roeder Kaiky Borges Lima Oliveira Lucas de Castro Gois Mateus Pereira Ferreira Jonatas Gomes da Silva |
| author_facet | Enock José Alves Goes Junior Jakson Santos Roeder Kaiky Borges Lima Oliveira Lucas de Castro Gois Mateus Pereira Ferreira Jonatas Gomes da Silva |
| author_sort | Enock José Alves Goes Junior |
| collection | DOAJ |
| description | In the present article it is described the validation of a simple, precise, accurate, rapid and low-cost UV spectrophotometric method for quantification of paracetamol in tablets. The method was linear in the range between 6.4 - 9.6 μg mL-1, presenting a good correlation coefficient (r = 0.9984) and adequate limits of quantification (2.64 μg mL-1) and detection (0.87 μg mL-1). Precision and analysis showed low coefficient of variation (< 4.0 %) and a good average recovery percentual (99.22% - reference and 101.78% - generic) was obtained. The method was applied for paracetamol determination in two tablet formulations and these results are in good accordance with the declared values of manufacturer, at a 95% confidence level. The experimental activity is simple, showing it to be used in experimental activities on teaching laboratories improve student learning.
DOI: http://dx.doi.org/10.17807/orbital.v10i7.1330
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| first_indexed | 2024-04-10T21:17:31Z |
| format | Article |
| id | doaj.art-7c9f164f967b449fb40e5fea1c426620 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:31Z |
| publishDate | 2018-12-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-7c9f164f967b449fb40e5fea1c4266202023-01-20T10:53:39ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282018-12-01107UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental AnalysisEnock José Alves Goes Junior0Jakson Santos Roeder1Kaiky Borges Lima Oliveira2Lucas de Castro Gois3Mateus Pereira Ferreira4Jonatas Gomes da Silva5Universidade Católica de BrasíliaUniversidade Católica de BrasíliaUniversidade Católica de BrasíliaUniversidade Católica de BrasíliaUniversidade Católica de BrasíliaUniversidade Federal do Oeste da BahiaIn the present article it is described the validation of a simple, precise, accurate, rapid and low-cost UV spectrophotometric method for quantification of paracetamol in tablets. The method was linear in the range between 6.4 - 9.6 μg mL-1, presenting a good correlation coefficient (r = 0.9984) and adequate limits of quantification (2.64 μg mL-1) and detection (0.87 μg mL-1). Precision and analysis showed low coefficient of variation (< 4.0 %) and a good average recovery percentual (99.22% - reference and 101.78% - generic) was obtained. The method was applied for paracetamol determination in two tablet formulations and these results are in good accordance with the declared values of manufacturer, at a 95% confidence level. The experimental activity is simple, showing it to be used in experimental activities on teaching laboratories improve student learning. DOI: http://dx.doi.org/10.17807/orbital.v10i7.1330 https://periodicos.ufms.br/index.php/orbital/article/view/16037paracetamolteaching laboratoriesUV spectrophotometryvalidation studies |
| spellingShingle | Enock José Alves Goes Junior Jakson Santos Roeder Kaiky Borges Lima Oliveira Lucas de Castro Gois Mateus Pereira Ferreira Jonatas Gomes da Silva UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis Orbital: The Electronic Journal of Chemistry paracetamol teaching laboratories UV spectrophotometry validation studies |
| title | UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis |
| title_full | UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis |
| title_fullStr | UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis |
| title_full_unstemmed | UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis |
| title_short | UV Spectrophotometry Method Validation for Quantification of Paracetamol in Tablet Formulations: A Proposal of Experimental Activity for Instrumental Analysis |
| title_sort | uv spectrophotometry method validation for quantification of paracetamol in tablet formulations a proposal of experimental activity for instrumental analysis |
| topic | paracetamol teaching laboratories UV spectrophotometry validation studies |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/16037 |
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