Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets

Abstract Background The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF). Following ligand binding, EGFR heterodimerizes with other HER family members, such as HER2 (human epide...

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Bibliographic Details
Main Authors: Miguel Nava, Pranabananda Dutta, Nathan R. Zemke, Robin Farias-Eisner, Jaydutt V. Vadgama, Yanyuan Wu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Medical Genomics
Subjects:
HER2
Breast Cancer
EGFR
Epigenetics
Chromatin
Next generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12920-019-0477-8

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