Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds
Novel boron-containing drugs have recently been suggested as a new class of pharmaceuticals. However, the majority of current boron-detection techniques require expensive facilities and/or tedious pretreatment methods. Thus, to develop a novel and convenient detection method for boron-based pharmace...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/10/2436 |
| _version_ | 1828138714787741696 |
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| author | Yoshihide Hattori Takuya Ogaki Miki Ishimura Yoichiro Ohta Mitsunori Kirihata |
| author_facet | Yoshihide Hattori Takuya Ogaki Miki Ishimura Yoichiro Ohta Mitsunori Kirihata |
| author_sort | Yoshihide Hattori |
| collection | DOAJ |
| description | Novel boron-containing drugs have recently been suggested as a new class of pharmaceuticals. However, the majority of current boron-detection techniques require expensive facilities and/or tedious pretreatment methods. Thus, to develop a novel and convenient detection method for boron-based pharmaceuticals, imine-type boron-chelating-ligands were previously synthesized for use in a fluorescent sensor for boronic acid containing compounds. However, the fluorescence quantum yield of the imine-type sensor was particularly low, and the sensor was easily decomposed in aqueous media. Thus, in this paper, we report the development of a novel, convenient, and stable fluorescent boron-sensor based on O- and N-chelation (i.e., 2-(pyridine-2yl)phenol), and a corresponding method for the quantitative and qualitative detection of boronic acid-containing compounds using this commercially available sensor is presented. |
| first_indexed | 2024-04-11T18:40:43Z |
| format | Article |
| id | doaj.art-7ca3110e71ba45649e9faea132837fd8 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T18:40:43Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-7ca3110e71ba45649e9faea132837fd82022-12-22T04:08:59ZengMDPI AGSensors1424-82202017-10-011710243610.3390/s17102436s17102436Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing CompoundsYoshihide Hattori0Takuya Ogaki1Miki Ishimura2Yoichiro Ohta3Mitsunori Kirihata4Research Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, JapanResearch Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, JapanResearch Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, JapanResearch Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, JapanResearch Center of Boron Neutron Capture Therapy, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, JapanNovel boron-containing drugs have recently been suggested as a new class of pharmaceuticals. However, the majority of current boron-detection techniques require expensive facilities and/or tedious pretreatment methods. Thus, to develop a novel and convenient detection method for boron-based pharmaceuticals, imine-type boron-chelating-ligands were previously synthesized for use in a fluorescent sensor for boronic acid containing compounds. However, the fluorescence quantum yield of the imine-type sensor was particularly low, and the sensor was easily decomposed in aqueous media. Thus, in this paper, we report the development of a novel, convenient, and stable fluorescent boron-sensor based on O- and N-chelation (i.e., 2-(pyridine-2yl)phenol), and a corresponding method for the quantitative and qualitative detection of boronic acid-containing compounds using this commercially available sensor is presented.https://www.mdpi.com/1424-8220/17/10/2436fluorescent boron sensorBNCTboron pharmaceuticalboron(III) complex |
| spellingShingle | Yoshihide Hattori Takuya Ogaki Miki Ishimura Yoichiro Ohta Mitsunori Kirihata Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds Sensors fluorescent boron sensor BNCT boron pharmaceutical boron(III) complex |
| title | Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds |
| title_full | Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds |
| title_fullStr | Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds |
| title_full_unstemmed | Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds |
| title_short | Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of Boronic Acid-Containing Compounds |
| title_sort | development and elucidation of a novel fluorescent boron sensor for the analysis of boronic acid containing compounds |
| topic | fluorescent boron sensor BNCT boron pharmaceutical boron(III) complex |
| url | https://www.mdpi.com/1424-8220/17/10/2436 |
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