The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.857164/full |
| _version_ | 1818199765670690816 |
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| author | Kaori Suyama Daisuke Sakai Masahiko Watanabe |
| author_facet | Kaori Suyama Daisuke Sakai Masahiko Watanabe |
| author_sort | Kaori Suyama |
| collection | DOAJ |
| description | It has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17 is induced in the pathology and their interactions with other inflammatory responses. This conscience review organizes current laboratory findings on this topic and present trajectory for full understanding on the role of IL-17 in pathology of intervertebral disc disease. |
| first_indexed | 2024-12-12T02:26:58Z |
| format | Article |
| id | doaj.art-7ca374a8fde04f5695fc3d58c678cf72 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T02:26:58Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-7ca374a8fde04f5695fc3d58c678cf722022-12-22T00:41:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-03-011010.3389/fcell.2022.857164857164The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive ReviewKaori Suyama0Daisuke Sakai1Masahiko Watanabe2Department of Anatomy and Cellular Biology, Basic Medical Science, Tokai University School of Medicine, Isehara, JapanDepartment of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, JapanDepartment of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, JapanIt has been reported that degenerated and herniated lumbar intervertebral discs show high expression of IL-17, suggesting that local immune reactions occur in patients with low back pain. While clinical sample analyses from different laboratories confirm this, it is not deeply not known on how IL-17 is induced in the pathology and their interactions with other inflammatory responses. This conscience review organizes current laboratory findings on this topic and present trajectory for full understanding on the role of IL-17 in pathology of intervertebral disc disease.https://www.frontiersin.org/articles/10.3389/fcell.2022.857164/fullinterleukin-17intervertebral discnucleus pulposusdisc herniationcytokine |
| spellingShingle | Kaori Suyama Daisuke Sakai Masahiko Watanabe The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review Frontiers in Cell and Developmental Biology interleukin-17 intervertebral disc nucleus pulposus disc herniation cytokine |
| title | The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review |
| title_full | The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review |
| title_fullStr | The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review |
| title_full_unstemmed | The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review |
| title_short | The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review |
| title_sort | role of il 17 mediated inflammatory processes in the pathogenesis of intervertebral disc degeneration and herniation a comprehensive review |
| topic | interleukin-17 intervertebral disc nucleus pulposus disc herniation cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.857164/full |
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