Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents
Introduction Disseminated carcinomatosis of the bone marrow in prostate cancer is rare and has a poor prognosis. Although strong evidence suggests that novel hormonal agents improve the prognosis of metastatic prostate cancer, their effectiveness in cases of disseminated carcinomatosis of the bone m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12611 |
| _version_ | 1797627742962843648 |
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| author | Keina Nozaki Hisashi Matsushima Hiyo Obikane Ryohei Nishimoto Ryo Tanaka Takeru Morishige Tomoko Masuda Haruki Kume |
| author_facet | Keina Nozaki Hisashi Matsushima Hiyo Obikane Ryohei Nishimoto Ryo Tanaka Takeru Morishige Tomoko Masuda Haruki Kume |
| author_sort | Keina Nozaki |
| collection | DOAJ |
| description | Introduction Disseminated carcinomatosis of the bone marrow in prostate cancer is rare and has a poor prognosis. Although strong evidence suggests that novel hormonal agents improve the prognosis of metastatic prostate cancer, their effectiveness in cases of disseminated carcinomatosis of the bone marrow remains unclear. Case presentation We encountered two cases of prostate cancer with disseminated carcinomatosis of the bone marrow at the time of initial diagnosis. One patient was treated with enzalutamide, abiraterone, docetaxel, cabazitaxel, denosumab, and radium‐223 and died 38 months after the initial diagnosis. The other patient was treated with apalutamide and denosumab, and had progression‐free survival for 17 months after the initial diagnosis. Conclusion These results suggest that novel hormonal agents may improve the prognosis of prostate cancer even in patients with disseminated carcinomatosis of the bone marrow. |
| first_indexed | 2024-03-11T10:28:39Z |
| format | Article |
| id | doaj.art-7ca780e084694444b0e26f409f5c5956 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-03-11T10:28:39Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-7ca780e084694444b0e26f409f5c59562023-11-15T06:01:08ZengWileyIJU Case Reports2577-171X2023-11-016632933310.1002/iju5.12611Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agentsKeina Nozaki0Hisashi Matsushima1Hiyo Obikane2Ryohei Nishimoto3Ryo Tanaka4Takeru Morishige5Tomoko Masuda6Haruki Kume7Department of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Diagnostic Pathology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology Tokyo Metropolitan Police Hospital Tokyo JapanDepartment of Urology The University of Tokyo Graduate School of Medicine Tokyo JapanIntroduction Disseminated carcinomatosis of the bone marrow in prostate cancer is rare and has a poor prognosis. Although strong evidence suggests that novel hormonal agents improve the prognosis of metastatic prostate cancer, their effectiveness in cases of disseminated carcinomatosis of the bone marrow remains unclear. Case presentation We encountered two cases of prostate cancer with disseminated carcinomatosis of the bone marrow at the time of initial diagnosis. One patient was treated with enzalutamide, abiraterone, docetaxel, cabazitaxel, denosumab, and radium‐223 and died 38 months after the initial diagnosis. The other patient was treated with apalutamide and denosumab, and had progression‐free survival for 17 months after the initial diagnosis. Conclusion These results suggest that novel hormonal agents may improve the prognosis of prostate cancer even in patients with disseminated carcinomatosis of the bone marrow.https://doi.org/10.1002/iju5.12611androgen receptor‐axis targeted agentsbone marrow involvementbone marrow metastasisnew hormonal agentsradium‐223 |
| spellingShingle | Keina Nozaki Hisashi Matsushima Hiyo Obikane Ryohei Nishimoto Ryo Tanaka Takeru Morishige Tomoko Masuda Haruki Kume Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents IJU Case Reports androgen receptor‐axis targeted agents bone marrow involvement bone marrow metastasis new hormonal agents radium‐223 |
| title | Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| title_full | Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| title_fullStr | Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| title_full_unstemmed | Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| title_short | Two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| title_sort | two cases of prostate cancer with disseminated carcinomatosis of the bone marrow treated with novel hormonal agents |
| topic | androgen receptor‐axis targeted agents bone marrow involvement bone marrow metastasis new hormonal agents radium‐223 |
| url | https://doi.org/10.1002/iju5.12611 |
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