Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14810 |
| _version_ | 1797447248046456832 |
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| author | Mario Ignacio Zelada Verónica Garrido Andrés Liberona Natalia Jones Karen Zúñiga Hernán Silva Rodrigo R. Nieto |
| author_facet | Mario Ignacio Zelada Verónica Garrido Andrés Liberona Natalia Jones Karen Zúñiga Hernán Silva Rodrigo R. Nieto |
| author_sort | Mario Ignacio Zelada |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression. |
| first_indexed | 2024-03-09T13:52:08Z |
| format | Article |
| id | doaj.art-7ca97f754bb64a0482fa961ea793a8ec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:52:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7ca97f754bb64a0482fa961ea793a8ec2023-11-30T20:48:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191481010.3390/ijms241914810Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic ReviewMario Ignacio Zelada0Verónica Garrido1Andrés Liberona2Natalia Jones3Karen Zúñiga4Hernán Silva5Rodrigo R. Nieto6Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileClínica Psiquiátrica Universitaria, Hospital Clínico de la Universidad de Chile, Universidad de Chile, Santiago 8380453, ChileClínica Psiquiátrica Universitaria, Hospital Clínico de la Universidad de Chile, Universidad de Chile, Santiago 8380453, ChileBrain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression.https://www.mdpi.com/1422-0067/24/19/14810neurotrophinsBDNFbiomarkerstreatment responsetreatment resistancetreatment refractoriness |
| spellingShingle | Mario Ignacio Zelada Verónica Garrido Andrés Liberona Natalia Jones Karen Zúñiga Hernán Silva Rodrigo R. Nieto Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review International Journal of Molecular Sciences neurotrophins BDNF biomarkers treatment response treatment resistance treatment refractoriness |
| title | Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review |
| title_full | Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review |
| title_fullStr | Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review |
| title_full_unstemmed | Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review |
| title_short | Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review |
| title_sort | brain derived neurotrophic factor bdnf as a predictor of treatment response in major depressive disorder mdd a systematic review |
| topic | neurotrophins BDNF biomarkers treatment response treatment resistance treatment refractoriness |
| url | https://www.mdpi.com/1422-0067/24/19/14810 |
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