Drug Candidate BGP-15 Prevents Isoproterenol-Induced Arrhythmias and Alters Heart Rate Variability (HRV) in Telemetry-Implanted Rats

Drug Candidate BGP-15 Prevents Isoproterenol-Induced Arrhythmias and Alters Heart Rate Variability (HRV) in Telemetry-Implanted Rats

Multi-target drug candidate BGP-15 has shown cardioprotective and antiarrhythmic actions in diseased models. Here, we investigated the effects of BGP-15 on ECG and echocardiographic parameters, heart rate variability (HRV), and arrhythmia incidence in telemetry-implanted rats, under beta-adrenergic...

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Bibliographic Details
Main Authors: Brigitta Bernat, Rita Erdelyi, Laszlo Fazekas, Greta Garami, Reka Maria Szekeres, Barbara Takacs, Mariann Bombicz, Balazs Varga, Fruzsina Sarkany, Arnold Peter Raduly, Dana Diana Romanescu, Zoltan Papp, Attila Toth, Zoltan Szilvassy, Bela Juhasz, Daniel Priksz
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
BGP-15
telemetry
arrhythmia
heart rate variability
isoproterenol
echocardiography
Online Access:https://www.mdpi.com/1424-8247/16/3/359

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