ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans

ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans

During macroautophagy, the human WIPI (WD-repeat protein interacting with phosphoinositides) proteins (WIPI1–4) function as phosphatidylinositol 3-phosphate effectors at the nascent autophagosome. Likewise, the two WIPI homologues in Caenorhabditis elegans, ATG-18 and EPG-6, play important...

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Bibliographic Details
Main Authors: Zsuzsanna Takacs, Katharina Sporbeck, Jennifer Stoeckle, Maria Jhaneth Prado Carvajal, Mona Grimmel, Tassula Proikas-Cezanne
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
ATG-18
autophagy
EPG-6
GFP::LGG-1
lifespan
WIPI3
WIPI4
Online Access:http://www.mdpi.com/2073-4409/8/3/236

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