Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome
Abstract Background A growing body of evidence indicated that vitamin D has a potential protective role against neurovascular injury. Low serum vitamin D has been associated with increased risk for incident stroke and stroke fatality. Objective This study aimed to investigate vitamin D status among...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-02-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41983-019-0068-9 |
| _version_ | 1811330723654664192 |
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| author | E. Fahmy S. Sharaf H. Helmy S. Sherif |
| author_facet | E. Fahmy S. Sharaf H. Helmy S. Sherif |
| author_sort | E. Fahmy |
| collection | DOAJ |
| description | Abstract Background A growing body of evidence indicated that vitamin D has a potential protective role against neurovascular injury. Low serum vitamin D has been associated with increased risk for incident stroke and stroke fatality. Objective This study aimed to investigate vitamin D status among acute ischemic stroke patients and examine its relation to initial severity and short-term outcome. Subjects and methods Forty-eight acute ischemic stroke patients and 48 matched healthy control subjects participated in the study. Subjects were divided according to vitamin D level into deficient, insufficient, and sufficient groups. National Institute of Health Stroke Scale (NIHSS) on admission and after 72 h and modified Rankin Scale (mRS) on discharge and after 3 months were performed for all patients. Results Stroke patients had significantly lower serum vitamin D levels compared to healthy subjects. Vitamin D deficiency and insufficiency were significantly prevalent among patients compared to healthy controls. Significant negative correlation was detected between serum vitamin D and NIHSS scores on admission and after 72 h. Significant negative correlation was also detected between serum vitamin D and mRS scores on discharge and after 3 months. An increased risk of stroke of 2.88 times was found in patients with insufficient vitamin D in comparison to sufficient subgroup, and this likelihood increases to be 13.78 times in the deficient compared to sufficient subgroups. Conclusion Vitamin D deficiency increases the risk of acute ischemic stroke and is associated with increased initial stroke severity and worse short-term outcome. |
| first_indexed | 2024-04-13T16:08:00Z |
| format | Article |
| id | doaj.art-7cabff76edf043b99fcf3e3820407694 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-13T16:08:00Z |
| publishDate | 2019-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-7cabff76edf043b99fcf3e38204076942022-12-22T02:40:21ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292019-02-015511610.1186/s41983-019-0068-9Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcomeE. Fahmy0S. Sharaf1H. Helmy2S. Sherif3Department of Neurology, Cairo UniversityClinical Pathology, Cairo UniversityDepartment of Neurology, Cairo UniversityDepartment of Neurology, Cairo UniversityAbstract Background A growing body of evidence indicated that vitamin D has a potential protective role against neurovascular injury. Low serum vitamin D has been associated with increased risk for incident stroke and stroke fatality. Objective This study aimed to investigate vitamin D status among acute ischemic stroke patients and examine its relation to initial severity and short-term outcome. Subjects and methods Forty-eight acute ischemic stroke patients and 48 matched healthy control subjects participated in the study. Subjects were divided according to vitamin D level into deficient, insufficient, and sufficient groups. National Institute of Health Stroke Scale (NIHSS) on admission and after 72 h and modified Rankin Scale (mRS) on discharge and after 3 months were performed for all patients. Results Stroke patients had significantly lower serum vitamin D levels compared to healthy subjects. Vitamin D deficiency and insufficiency were significantly prevalent among patients compared to healthy controls. Significant negative correlation was detected between serum vitamin D and NIHSS scores on admission and after 72 h. Significant negative correlation was also detected between serum vitamin D and mRS scores on discharge and after 3 months. An increased risk of stroke of 2.88 times was found in patients with insufficient vitamin D in comparison to sufficient subgroup, and this likelihood increases to be 13.78 times in the deficient compared to sufficient subgroups. Conclusion Vitamin D deficiency increases the risk of acute ischemic stroke and is associated with increased initial stroke severity and worse short-term outcome.http://link.springer.com/article/10.1186/s41983-019-0068-9Acute ischemic strokeVitamin DStroke severityStroke outcome |
| spellingShingle | E. Fahmy S. Sharaf H. Helmy S. Sherif Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Acute ischemic stroke Vitamin D Stroke severity Stroke outcome |
| title | Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome |
| title_full | Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome |
| title_fullStr | Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome |
| title_full_unstemmed | Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome |
| title_short | Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome |
| title_sort | vitamin d status in acute ischemic stroke relation to initial severity and short term outcome |
| topic | Acute ischemic stroke Vitamin D Stroke severity Stroke outcome |
| url | http://link.springer.com/article/10.1186/s41983-019-0068-9 |
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