The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients
This study aims to analyse the results of specific IgE to molecular components of PR 10 proteins, mould and yeast in atopic dermatitis (AD) patients, to find significant sets of molecular components in pairs and triplets in the relation to the severity of atopic dermatitis and the occurrence of asth...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2022.2130183 |
| _version_ | 1797990715183071232 |
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| author | J. Čelakovská R. Vaňková H. Skalská J. Krejsek C. Andrýs |
| author_facet | J. Čelakovská R. Vaňková H. Skalská J. Krejsek C. Andrýs |
| author_sort | J. Čelakovská |
| collection | DOAJ |
| description | This study aims to analyse the results of specific IgE to molecular components of PR 10 proteins, mould and yeast in atopic dermatitis (AD) patients, to find significant sets of molecular components in pairs and triplets in the relation to the severity of atopic dermatitis and the occurrence of asthma bronchiale and allergic rhinitis. The examination of the sensitization to molecular components with ALEX2 Allergy Explorer testing was performed. The level of specific IgE was recorded with Jittered box plots, the Kruskal–Wallis test was used to compare the level of specific IgE in different forms of AD. The relation between the results of specific IgE was evaluated with Coefficient of correlation (Kendall tau-b). The comparison of significant rules was performed with Fisher–Freeman–Halton exact test and with tests on proportions. Altogether 100 atopic dermatitis patients were examined. Molecular components Fra a 1 + 3, Mal d 1, Api g 1, Mala s 11 and Asp f 6 are recorded as a single molecular component with relation to the severe form of AD; these components are associated in pairs and triplets with molecular components Cor a 1.0401, Cor a 1.0103, Fag s 1, Alt a 1 and with the occurrence of allergic rhinitis. Results are presented in static and interactive tables and plots. |
| first_indexed | 2024-04-11T08:41:09Z |
| format | Article |
| id | doaj.art-7cad9b96a0fd4e42a08faa3cf61bb618 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-04-11T08:41:09Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-7cad9b96a0fd4e42a08faa3cf61bb6182022-12-22T04:34:12ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432022-12-0133178079810.1080/09540105.2022.2130183The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patientsJ. Čelakovská0R. Vaňková1H. Skalská2J. Krejsek3C. Andrýs4Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Informatics and Quantitative Methods, University of Hradec Králové, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicThis study aims to analyse the results of specific IgE to molecular components of PR 10 proteins, mould and yeast in atopic dermatitis (AD) patients, to find significant sets of molecular components in pairs and triplets in the relation to the severity of atopic dermatitis and the occurrence of asthma bronchiale and allergic rhinitis. The examination of the sensitization to molecular components with ALEX2 Allergy Explorer testing was performed. The level of specific IgE was recorded with Jittered box plots, the Kruskal–Wallis test was used to compare the level of specific IgE in different forms of AD. The relation between the results of specific IgE was evaluated with Coefficient of correlation (Kendall tau-b). The comparison of significant rules was performed with Fisher–Freeman–Halton exact test and with tests on proportions. Altogether 100 atopic dermatitis patients were examined. Molecular components Fra a 1 + 3, Mal d 1, Api g 1, Mala s 11 and Asp f 6 are recorded as a single molecular component with relation to the severe form of AD; these components are associated in pairs and triplets with molecular components Cor a 1.0401, Cor a 1.0103, Fag s 1, Alt a 1 and with the occurrence of allergic rhinitis. Results are presented in static and interactive tables and plots.https://www.tandfonline.com/doi/10.1080/09540105.2022.2130183Atopic dermatitisALEX2 Allergy explorermolecular componentsseverity of atopic dermatitisdisturbed epidermal barrierasthma bronchiale |
| spellingShingle | J. Čelakovská R. Vaňková H. Skalská J. Krejsek C. Andrýs The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients Food and Agricultural Immunology Atopic dermatitis ALEX2 Allergy explorer molecular components severity of atopic dermatitis disturbed epidermal barrier asthma bronchiale |
| title | The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| title_full | The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| title_fullStr | The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| title_full_unstemmed | The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| title_short | The role of PR 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| title_sort | role of pr 10 proteins and molecular components of moulds and yeast in atopic dermatitis patients |
| topic | Atopic dermatitis ALEX2 Allergy explorer molecular components severity of atopic dermatitis disturbed epidermal barrier asthma bronchiale |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2022.2130183 |
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