Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature
Abstract Background Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedingly rare case of GHAC resulting in a spontaneous gastric perforation....
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3357-7 |
| _version_ | 1819080398913667072 |
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| author | Junichi Yoshizawa Satoshi Ishizone Meguru Ikeyama Jun Nakayama |
| author_facet | Junichi Yoshizawa Satoshi Ishizone Meguru Ikeyama Jun Nakayama |
| author_sort | Junichi Yoshizawa |
| collection | DOAJ |
| description | Abstract Background Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedingly rare case of GHAC resulting in a spontaneous gastric perforation. Case presentation A 61-year-old man presented at our institution complaining of abdominal and back pain. A computed tomography scan revealed a spontaneous gastric perforation with a solitary liver tumor and lymph node swelling. Following a diagnosis of advanced-stage GC with a gastric perforation, perforative peritonitis, multiple lymph node metastases, and a solitary metastasis of the lateral segment of the liver, the patient underwent distal gastrectomy. Histopathology of the resected specimen revealed that the tumor cells were arranged in a hepatoid pattern. On immunohistochemical staining, the tumor cells were positive for alpha-fetoprotein and Sal-like protein 4. Thus, the patient was diagnosed with GHAC. Hepatic resection of the solitary liver metastasis was performed. However, recurrence occurred and the patient achieved complete response following tegafur/gimeracil/oteracil-based chemotherapy. Conclusions GHAC is a highly malignant histological subtype of GC. We reported on an extremely rare case of GHAC resulting in a spontaneous gastric perforation and reviewed the literature, including epidemiological data, treatment regimens, and the association between GHAC and alpha-fetoprotein-producing GC. |
| first_indexed | 2024-12-21T19:44:15Z |
| format | Article |
| id | doaj.art-7caee1c0a8bb462da584f21f2a39942d |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-21T19:44:15Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7caee1c0a8bb462da584f21f2a39942d2022-12-21T18:52:22ZengBMCBMC Cancer1471-24072017-05-011711710.1186/s12885-017-3357-7Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literatureJunichi Yoshizawa0Satoshi Ishizone1Meguru Ikeyama2Jun Nakayama3Department of Surgery, North Alps Medical Center Azumi HospitalDepartment of Surgery, North Alps Medical Center Azumi HospitalDepartment of Molecular Pathology, Shinshu University Graduate School of MedicineDepartment of Molecular Pathology, Shinshu University Graduate School of MedicineAbstract Background Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedingly rare case of GHAC resulting in a spontaneous gastric perforation. Case presentation A 61-year-old man presented at our institution complaining of abdominal and back pain. A computed tomography scan revealed a spontaneous gastric perforation with a solitary liver tumor and lymph node swelling. Following a diagnosis of advanced-stage GC with a gastric perforation, perforative peritonitis, multiple lymph node metastases, and a solitary metastasis of the lateral segment of the liver, the patient underwent distal gastrectomy. Histopathology of the resected specimen revealed that the tumor cells were arranged in a hepatoid pattern. On immunohistochemical staining, the tumor cells were positive for alpha-fetoprotein and Sal-like protein 4. Thus, the patient was diagnosed with GHAC. Hepatic resection of the solitary liver metastasis was performed. However, recurrence occurred and the patient achieved complete response following tegafur/gimeracil/oteracil-based chemotherapy. Conclusions GHAC is a highly malignant histological subtype of GC. We reported on an extremely rare case of GHAC resulting in a spontaneous gastric perforation and reviewed the literature, including epidemiological data, treatment regimens, and the association between GHAC and alpha-fetoprotein-producing GC.http://link.springer.com/article/10.1186/s12885-017-3357-7Alpha-fetoproteinCase reportGastric cancerGastric perforationHepatoid adenocarcinoma |
| spellingShingle | Junichi Yoshizawa Satoshi Ishizone Meguru Ikeyama Jun Nakayama Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature BMC Cancer Alpha-fetoprotein Case report Gastric cancer Gastric perforation Hepatoid adenocarcinoma |
| title | Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature |
| title_full | Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature |
| title_fullStr | Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature |
| title_full_unstemmed | Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature |
| title_short | Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature |
| title_sort | gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation a case report and review of the literature |
| topic | Alpha-fetoprotein Case report Gastric cancer Gastric perforation Hepatoid adenocarcinoma |
| url | http://link.springer.com/article/10.1186/s12885-017-3357-7 |
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