Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction
OBJECTIVE: Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. The aims of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) in patients with acute myocardial infa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2013-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000100013 |
| _version_ | 1811330458164658176 |
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| author | Ying-Qing Li Mei-Fen Zhang Hong-Yan Wen Chun-Lin Hu Rong Liu Hong-Yan Wei Chen-Mu Ai Gang Wang Xiao-Xing Liao Xin Li |
| author_facet | Ying-Qing Li Mei-Fen Zhang Hong-Yan Wen Chun-Lin Hu Rong Liu Hong-Yan Wei Chen-Mu Ai Gang Wang Xiao-Xing Liao Xin Li |
| author_sort | Ying-Qing Li |
| collection | DOAJ |
| description | OBJECTIVE: Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. The aims of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) in patients with acute myocardial infarction and to compare the diagnostic values of these miRNAs with that of cardiac troponin T. METHODS: Sixty-seven plasma samples obtained from patients with acute myocardial infarction and 32 plasma specimens collected from healthy volunteers were analyzed in this study. The levels of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) were measured by quantitative reverse transcription-polymerase chain reaction, and the concentrations of plasma cardiac troponin T were measured using electrochemiluminescence-based methods and an Elecsys 2010 Immunoassay Analyzer. RESULTS: The levels of plasma miR-1, -133a, -208b, and -499 were significantly higher in acute myocardial infarction patients (all p<0.001) than in healthy volunteers. The expression of the cardiac-specific miRNAs in acute myocardial infarction patients decreased to close to the baseline levels at the time of hospital discharge (all p>0.05). There were no correlations between the levels of the four circulating miRNAs and the clinical characteristics of the study population (all p>0.05). Furthermore, receiver operating characteristic curve analyses showed that the four plasma miRNAs were not superior to cardiac troponin T for the diagnosis of acute myocardial infarction (all p>0.05). CONCLUSION: Our results demonstrate that circulating miR-1, -133a, -208b, and -499 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction. |
| first_indexed | 2024-04-13T16:02:02Z |
| format | Article |
| id | doaj.art-7caef7edceee4b2b829f727ef0f4d840 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T16:02:02Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-7caef7edceee4b2b829f727ef0f4d8402022-12-22T02:40:30ZengElsevier EspañaClinics1807-59321980-53222013-01-016817580Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarctionYing-Qing LiMei-Fen ZhangHong-Yan WenChun-Lin HuRong LiuHong-Yan WeiChen-Mu AiGang WangXiao-Xing LiaoXin LiOBJECTIVE: Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. The aims of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) in patients with acute myocardial infarction and to compare the diagnostic values of these miRNAs with that of cardiac troponin T. METHODS: Sixty-seven plasma samples obtained from patients with acute myocardial infarction and 32 plasma specimens collected from healthy volunteers were analyzed in this study. The levels of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) were measured by quantitative reverse transcription-polymerase chain reaction, and the concentrations of plasma cardiac troponin T were measured using electrochemiluminescence-based methods and an Elecsys 2010 Immunoassay Analyzer. RESULTS: The levels of plasma miR-1, -133a, -208b, and -499 were significantly higher in acute myocardial infarction patients (all p<0.001) than in healthy volunteers. The expression of the cardiac-specific miRNAs in acute myocardial infarction patients decreased to close to the baseline levels at the time of hospital discharge (all p>0.05). There were no correlations between the levels of the four circulating miRNAs and the clinical characteristics of the study population (all p>0.05). Furthermore, receiver operating characteristic curve analyses showed that the four plasma miRNAs were not superior to cardiac troponin T for the diagnosis of acute myocardial infarction (all p>0.05). CONCLUSION: Our results demonstrate that circulating miR-1, -133a, -208b, and -499 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000100013microRNAscardiac troponin TAcute Myocardial InfarctionCirculating Biomarkers |
| spellingShingle | Ying-Qing Li Mei-Fen Zhang Hong-Yan Wen Chun-Lin Hu Rong Liu Hong-Yan Wei Chen-Mu Ai Gang Wang Xiao-Xing Liao Xin Li Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction Clinics microRNAs cardiac troponin T Acute Myocardial Infarction Circulating Biomarkers |
| title | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction |
| title_full | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction |
| title_fullStr | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction |
| title_full_unstemmed | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction |
| title_short | Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction |
| title_sort | comparing the diagnostic values of circulating micrornas and cardiac troponin t in patients with acute myocardial infarction |
| topic | microRNAs cardiac troponin T Acute Myocardial Infarction Circulating Biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000100013 |
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