Reciprocal expression of Slug and Snail in human oral cancer cells.
Snail, also called Snai1, is a key regulator of EMT. Snail plays crucial roles in cancer progression, including resistance to anti-tumor drugs and invasion by various cancer cells. Slug, also known as Snai2, is also involved in the aggravation of certain tumors. In this study, we examined the roles...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6029773?pdf=render |
| _version_ | 1818026083830726656 |
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| author | Ryosuke Nakamura Hiroki Ishii Kaori Endo Asami Hotta Eiji Fujii Keiji Miyazawa Masao Saitoh |
| author_facet | Ryosuke Nakamura Hiroki Ishii Kaori Endo Asami Hotta Eiji Fujii Keiji Miyazawa Masao Saitoh |
| author_sort | Ryosuke Nakamura |
| collection | DOAJ |
| description | Snail, also called Snai1, is a key regulator of EMT. Snail plays crucial roles in cancer progression, including resistance to anti-tumor drugs and invasion by various cancer cells. Slug, also known as Snai2, is also involved in the aggravation of certain tumors. In this study, we examined the roles of Slug in human oral squamous cell carcinoma (OSCC) cells. Slug is highly expressed in these cells, and Slug siRNA effectively represses anti-tumor drug resistance and invasive properties. In addition, transforming growth factor (TGF)-β upregulates the expression of Snail and Slug and promotes resistance to anti-tumor drugs in OSCC cells. Surprisingly, Slug siRNA appears to upregulate Snail expression considerably in OSCC cells. Snail siRNA also appears to upregulate Slug expression. Thus, either Slug or Snail siRNA alone partially mitigates malignant phenotypes in the presence of TGF-β, whereas both Slug and Snail siRNAs together dramatically suppress them. Therefore, Slug and Snail in tandem, but not alone, are potential therapeutic targets for nucleic acid medicines to treat oral cancer. |
| first_indexed | 2024-12-10T04:26:22Z |
| format | Article |
| id | doaj.art-7caf16414c254e5ab3467dbe0fc4f3e8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T04:26:22Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7caf16414c254e5ab3467dbe0fc4f3e82022-12-22T02:02:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019944210.1371/journal.pone.0199442Reciprocal expression of Slug and Snail in human oral cancer cells.Ryosuke NakamuraHiroki IshiiKaori EndoAsami HottaEiji FujiiKeiji MiyazawaMasao SaitohSnail, also called Snai1, is a key regulator of EMT. Snail plays crucial roles in cancer progression, including resistance to anti-tumor drugs and invasion by various cancer cells. Slug, also known as Snai2, is also involved in the aggravation of certain tumors. In this study, we examined the roles of Slug in human oral squamous cell carcinoma (OSCC) cells. Slug is highly expressed in these cells, and Slug siRNA effectively represses anti-tumor drug resistance and invasive properties. In addition, transforming growth factor (TGF)-β upregulates the expression of Snail and Slug and promotes resistance to anti-tumor drugs in OSCC cells. Surprisingly, Slug siRNA appears to upregulate Snail expression considerably in OSCC cells. Snail siRNA also appears to upregulate Slug expression. Thus, either Slug or Snail siRNA alone partially mitigates malignant phenotypes in the presence of TGF-β, whereas both Slug and Snail siRNAs together dramatically suppress them. Therefore, Slug and Snail in tandem, but not alone, are potential therapeutic targets for nucleic acid medicines to treat oral cancer.http://europepmc.org/articles/PMC6029773?pdf=render |
| spellingShingle | Ryosuke Nakamura Hiroki Ishii Kaori Endo Asami Hotta Eiji Fujii Keiji Miyazawa Masao Saitoh Reciprocal expression of Slug and Snail in human oral cancer cells. PLoS ONE |
| title | Reciprocal expression of Slug and Snail in human oral cancer cells. |
| title_full | Reciprocal expression of Slug and Snail in human oral cancer cells. |
| title_fullStr | Reciprocal expression of Slug and Snail in human oral cancer cells. |
| title_full_unstemmed | Reciprocal expression of Slug and Snail in human oral cancer cells. |
| title_short | Reciprocal expression of Slug and Snail in human oral cancer cells. |
| title_sort | reciprocal expression of slug and snail in human oral cancer cells |
| url | http://europepmc.org/articles/PMC6029773?pdf=render |
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