Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study
Introduction: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. Variety of inflammatory mediators participate in the regulation of melanogenesis in melanocytes: interleukin-18 (IL-18), interleukin-33, granulocyte-macrophage colony stimulating factor, inte...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222300152X |
| _version_ | 1797894742110896128 |
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| author | Barbara Nieradko-Iwanicka Daria Przybylska Andrzej Borzęcki |
| author_facet | Barbara Nieradko-Iwanicka Daria Przybylska Andrzej Borzęcki |
| author_sort | Barbara Nieradko-Iwanicka |
| collection | DOAJ |
| description | Introduction: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. Variety of inflammatory mediators participate in the regulation of melanogenesis in melanocytes: interleukin-18 (IL-18), interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1 (IL-1), interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis. Aim: Evaluation of IL-1α and IL-18 levels in peripheral blood in patients with vitiligo compared to healthy controls. Materials and methods: Fifty patients aged 18–81 with vitiligo participated in the study. The control group consisted of 38 healthy people. Venous blood samples were obtained from each participant. Serum IL-1α and IL-18 concentrations were determined using the enzyme-linked immunoabsorbent assay (ELISA). Results: Among patients with vitiligo, the mean concentration of IL-1α was 0.13 (± 0.535) pg/mL, while in the control group it was 0.51 (± 1.51). There were no statistically significant differences in IL-1α concentrations between patients in the study group compared to the control group (p > 0.05). In the study group, the mean IL-18 concentration was 141.05 (± 136.33) pg/mL vs 137.33 (± 105.83) pg/mL in the controls. There were no statistically significant differences in IL-18 concentrations between patients in the study group compared to the controls (p > 0.05). In the Spearman correlation test, no correlation was confirmed between IL1α and IL-18 concentrations in the group of patients with vitiligo vs healthy people. Conclusions: There is no correlation between Il-1 and Il-18 concentration in the blood sera of patients with vitiligo. |
| first_indexed | 2024-04-10T07:14:08Z |
| format | Article |
| id | doaj.art-7caf96ab21424c9b9b2e07ec86a80160 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T07:14:08Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7caf96ab21424c9b9b2e07ec86a801602023-02-26T04:26:35ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-04-01160114364Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control studyBarbara Nieradko-Iwanicka0Daria Przybylska1Andrzej Borzęcki2Department of Hygiene and Epidemiology, Medical University of Lublin, Chodźki 7 Street, 20-093 Lublin, Poland; Corresponding author.Department of Dermatology, Venerology and Pediatric Dermatology, Independent Public Healthcare Unit No.1 in Lublin, Staszica 16 Street, 20-081 Lublin, PolandDepartment of Hygiene and Epidemiology, Medical University of Lublin, Chodźki 7 Street, 20-093 Lublin, PolandIntroduction: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. Variety of inflammatory mediators participate in the regulation of melanogenesis in melanocytes: interleukin-18 (IL-18), interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1 (IL-1), interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis. Aim: Evaluation of IL-1α and IL-18 levels in peripheral blood in patients with vitiligo compared to healthy controls. Materials and methods: Fifty patients aged 18–81 with vitiligo participated in the study. The control group consisted of 38 healthy people. Venous blood samples were obtained from each participant. Serum IL-1α and IL-18 concentrations were determined using the enzyme-linked immunoabsorbent assay (ELISA). Results: Among patients with vitiligo, the mean concentration of IL-1α was 0.13 (± 0.535) pg/mL, while in the control group it was 0.51 (± 1.51). There were no statistically significant differences in IL-1α concentrations between patients in the study group compared to the control group (p > 0.05). In the study group, the mean IL-18 concentration was 141.05 (± 136.33) pg/mL vs 137.33 (± 105.83) pg/mL in the controls. There were no statistically significant differences in IL-18 concentrations between patients in the study group compared to the controls (p > 0.05). In the Spearman correlation test, no correlation was confirmed between IL1α and IL-18 concentrations in the group of patients with vitiligo vs healthy people. Conclusions: There is no correlation between Il-1 and Il-18 concentration in the blood sera of patients with vitiligo.http://www.sciencedirect.com/science/article/pii/S075333222300152XInterleukin 1αInterleukin 18Vitiligo |
| spellingShingle | Barbara Nieradko-Iwanicka Daria Przybylska Andrzej Borzęcki Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study Biomedicine & Pharmacotherapy Interleukin 1α Interleukin 18 Vitiligo |
| title | Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study |
| title_full | Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study |
| title_fullStr | Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study |
| title_full_unstemmed | Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study |
| title_short | Interleukin 1α and interleukin 18 in patients with vitiligo – Results of a case-control study |
| title_sort | interleukin 1α and interleukin 18 in patients with vitiligo results of a case control study |
| topic | Interleukin 1α Interleukin 18 Vitiligo |
| url | http://www.sciencedirect.com/science/article/pii/S075333222300152X |
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